Clinical Trial

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

Recruiting Phase 3
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Record status
This record was last updated December 16, 2025 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-05-21; most recent amendment 2025-12-10.
Status change: Not Yet Recruiting → Recruiting 2025-10-23
Trial Details
NCT Number NCT06996951
Lead Sponsor Indiana University
Collaborators: American Rhinologic Society
Conditions Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS)
Enrollment 64 participants
Start Date 2025-07-02
Primary Completion 2026-07 (estimated)
Study Completion 2026-07 (estimated)
Updated on ClinicalTrials.gov 2025-12-16