Disease landscape

Cystic Fibrosis clinical trials

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198 active trials 120 recruiting 10 Phase 3 126 sponsors 27 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days

2026-09-15
Primary completion pushed: 2026-05-01 → 2026-09-10
Completion pushed: 2026-12-31 → 2027-05-01
NCT04259970 Hyperpolarized Imaging for New Treatments · Children's Hospital Medical Center, Cincinnati · Phase 4
2026-09-10
Primary completion pushed: 2029-04-01 → 2029-07-01
Primary endpoint(s) modified
Enrollment reduced: 237 → 206 participants
Interventions modified
NCT04602468 Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF… · Royal College of Surgeons, Ireland · Phase 4
2026-09-15
Primary endpoint(s) modified
NCT07809867 Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis · Istituto Giannina Gaslini · Phase 4
2026-08-20
Enrollment reduced: 192 → 128 participants
Enrollment closed, study ongoing
Primary completion pushed: 2026-08-30 → 2026-11
Completion moved earlier: 2026-12-31 → 2026-11
NCT06237335 A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy… · ReCode Therapeutics · Phase 2
2026-09-11
Trial completed
NCT07108153 Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and… · Sionna Therapeutics Inc. · Phase 2
2026-09-11
Trial completed
Final enrollment: 120 participants (planned 144)
Primary completion confirmed: March 2026 (last estimated June 2026)
NCT07035990 Safety, Tolerability, and Pharmacokinetics of Multiple Dose Combinations of SION-451 and… · Sionna Therapeutics Inc. · Phase 1
2026-08-26
Phase changed: Early Phase 1 → not specified
Primary completion pushed: 2026-07-31 → 2026-09-01
Completion moved earlier: 2026-12-30 → 2026-11-01
NCT06163482 Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis · University of Cincinnati
2026-09-01
Sponsor changed: University of Pennsylvania → Michael R. Rickels, MD, MS
NCT06995651 Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis · Michael R. Rickels, MD, MS · Phase 1
2026-08-22
Enrollment closed, study ongoing
NCT06810167 Assessing Tenapanor as a Treatment of CF-related Constipation. · Massachusetts General Hospital · Phase 3
2026-09-16
Results posted: 2026-09-15
NCT03489629 STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) · University of North Carolina, Chapel Hill · Phase 2
2026-09-15
Completion pushed: 2026-01-01 → 2027-01-01
NCT04549077 Pulmonary Vascular Disease in CF · Children's Hospital Medical Center, Cincinnati
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06539169 FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases · xCures
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06587126 Feasibility of Cough Monitoring in Children · University of Colorado, Denver
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06546943 Glucose Monitoring in Youth With Cystic Fibrosis During Pulmonary Exacerbations · University of Colorado, Denver
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06274840 COVID-19 Antibody Responses In Cystic Fibrosis · Pilar Azevedo
2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
NCT05795673 Peer-supporting for Teenagers With Cystic Fibrosis in the Transition of Care From… · Hospices Civils de Lyon

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-09 NCT07809867 Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Istituto Giannina Gaslini new Phase 4
2026-07-09 NCT07692594 Heart and Blood Vessels Health in People With Cystic Fibrosis Liverpool Heart and Chest Hospital NHS Foundation Trust new
2026-07-07 NCT07688070 Verapamil Effect in Cystic Fibrosis-related Dysglycemia Rhode Island Hospital new Phase 2
2026-06-24 NCT07665203 Home Air Pollution in Children With Cystic Fibrosis Study Seattle Children's Hospital new

Active trials by phase

Early Phase 1
5
Phase 1
9
Phase 1/2
3
Phase 2
14
Phase 2/3
2
Phase 3
8
Phase 4
9
Not charted: 148 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 198

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05548283 Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study Chris Goss Recruiting 2026-07-08
NCT07148739 Ensuring Access to Optimal Therapy in CF: The ENACT Study Arkansas Children's Hospital Research Institute Recruiting 2026-06-02
NCT03921060 Markers of Osteoporosis in Cystic Fibrosis University of Texas Southwestern Medical Center Recruiting 2026-05-05
NCT05704036 Estrogen Supplementation and Bone Health in Women With CF Johns Hopkins University Recruiting 2025-11-14
NCT05517655 BEGIN Novel ImagiNG Biomarkers Children's Hospital Medical Center, Cincinnati Recruiting 2024-11-21
NCT04259970 Hyperpolarized Imaging for New Treatments Children's Hospital Medical Center, Cincinnati Active, Not Recruiting 2026-09-14
NCT07809867 Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Istituto Giannina Gaslini Not Yet Recruiting 2026-09-14
NCT04602468 Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF… Royal College of Surgeons, Ireland Active, Not Recruiting 2026-09-09
NCT04467957 Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis Children's Hospital Medical Center, Cincinnati Active, Not Recruiting 2026-01-28
Phase 3
NCT06449677 Bionic Pancreas in CFRD Jaeb Center for Health Research Recruiting 2026-06-24
NCT06996951 Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the… Indiana University Recruiting 2025-12-16
NCT05331183 Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-09-10
NCT05444257 A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-09-10
NCT06810167 Assessing Tenapanor as a Treatment of CF-related Constipation. Massachusetts General Hospital Active, Not Recruiting 2026-08-21
NCT06460506 Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-06-05
NCT05422222 Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-05-28
NCT05844449 Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in… Vertex Pharmaceuticals Incorporated Enrolling by Invitation 2026-04-29
Phase 2/3
NCT06413368 Maralixibat in Patients With Cystic Fibrosis and Constipation Children's Hospital Los Angeles Recruiting 2026-04-21
NCT06149793 SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes University of Minnesota Active, Not Recruiting 2026-01-20
Phase 2
NCT07450547 Phase 2 Study to Assess the Safety and Efficacy of ANG003 Anagram Therapeutics, Inc. Recruiting 2026-08-27
NCT05248230 4D-710 in Adult Patients With Cystic Fibrosis 4D Molecular Therapeutics Recruiting 2026-07-06
NCT04731272 GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance University of Pennsylvania Recruiting 2026-05-18
NCT06429176 Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients… SpliSense Ltd. Recruiting 2026-05-14
NCT06747858 Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis Arcturus Therapeutics, Inc. Recruiting 2026-05-08
NCT04530383 Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function University of Kansas Medical Center Recruiting 2026-04-15
See all 198 active Cystic Fibrosis trials with filters →

Top sponsors by active trials in this area

Vertex Pharmaceuticals Incorporated (9) · Children's Hospital Medical Center, Cincinnati (8) · University of North Carolina, Chapel Hill (5) · Hospices Civils de Lyon (4) · Indiana University (4) · Johns Hopkins University (4) · Riphah International University (4) · The Hospital for Sick Children (4) · University of British Columbia (4) · Emory University (3)

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