Sponsor Pipeline

UNC Lineberger Comprehensive Cancer Center Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-08-16
120
Active Trials
78
Recruiting
10
Disease Areas
24
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-08-15 NCT04073966
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly…
Enrollment reopened
2026-08-15 NCT04073966
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly…
Enrollment increased: 15 -> 20 participants
2026-08-15 NCT04073966
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly…
date change Primary completion pushed: 2027-05-28 -> 2028-05-31
2026-08-15 NCT04073966
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly…
date change Completion pushed: 2027-05-28 -> 2029-05-31
2026-08-14 NCT06618300
Streamlined Resin Y90 Radiation Segmentectomy for Small HCC
overall status: Enrolling by Invitation → Active, Not Recruiting
2026-08-07 NCT06090864
ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells
date change Primary completion pushed: 2026-07-01 -> 2028-08-03
2026-08-07 NCT06090864
ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells
date change Completion pushed: 2031-07-01 -> 2033-07-01
2026-08-04 NCT07634653
Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic…
Recruitment opened
2026-08-01 NCT03696784
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
Primary endpoint(s) modified
2026-08-01 NCT03696784
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
Enrollment reduced: 19 -> 12 participants
2026-07-31 NCT04585893
Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in Malawi
Trial completed
2026-07-30 NCT03264131
BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma
Trial completed
2026-07-30 NCT03264131
BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma
date change Completion moved earlier: 2028-12-15 -> 2025-12-15
2026-07-28 NCT05754749
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
critical Trial terminated
2026-07-28 NCT05754749
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
critical Trial terminated: Funding unavailable
2026-07-28 NCT05754749
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
Enrollment reduced: 20 -> 4 participants
2026-07-28 NCT05754749
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
date change Primary completion moved earlier: 2026-08-22 -> 2026-05-20
2026-07-28 NCT05754749
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
date change Completion moved earlier: 2026-08-22 -> 2026-05-20
2026-07-24 NCT06073067
GRID Therapy for Extremity Soft Tissue Sarcoma
date change Primary completion pushed: 2026-08-15 -> 2026-11-10
2026-07-24 NCT06073067
GRID Therapy for Extremity Soft Tissue Sarcoma
date change Completion pushed: 2026-08-15 -> 2027-11-10
Showing 20 of 24 changes detected in the last 30 days.
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-08-03 NCT07740941 NeoAdjuvant, Spare-Adjuvant (NASA) in Stage IIIB-IV (M1a) Melanoma Phase 2 Not Yet Recruiting
Active Trials by Phase
Phase 2
27
Phase 1/2
4
Phase 1
17
Early Phase 1
3
Not specified
69
Active Trials — top 25 of 120
NCT IDTitleConditionStatus
Phase 2
NCT04083495 CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma Peripheral T Cell Lymphoma Recruiting
NCT03977233 Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer Pancreatic Ductal Adenocarcinoma (PDAC) Recruiting
NCT07278557 Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia Head and Neck Cancer Recruiting
NCT05578326 Study of Trilaciclib and Lurbinectidin Lung Cancer Recruiting
NCT06902311 Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous… Breast Cancer Recruiting
NCT07069595 PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease Breast Cancer Recruiting
NCT07276880 Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion… Breast Cancer Recruiting
NCT06727773 Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of… Breast Cancer Recruiting
NCT05472792 Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation… Breast Cancer Recruiting
NCT05145400 Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma Multiple Myeloma Recruiting
NCT07225114 Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging Breast Cancer Recruiting
NCT07340541 Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies Breast Cancer Recruiting
NCT03978624 Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer Bladder Cancer Active, Not Recruiting
NCT05366166 Pembrolizumab Plus Olaparib in LA-HNSCC Squamous Cell Carcinoma of Head and Neck Active, Not Recruiting
NCT03174275 Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and… Carcinoma, Squamous Cell Active, Not Recruiting
NCT07484139 H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in… Oral Cavity Squamous Cell Carcinoma Not Yet Recruiting
NCT07545746 Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in… HIV Infections Not Yet Recruiting
NCT07078838 Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1… Endometrial Cancer Not Yet Recruiting
NCT05911321 Isa-Pom-Dex in Elderly/Frail Subjects With RRMM Multiple Myeloma Active, Not Recruiting
NCT04548648 A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas Central Nervous System Lymphoma Active, Not Recruiting
NCT03529422 Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN Larynx Active, Not Recruiting
NCT07605949 Revumenib, Azacitidine, and VENetoclax in Newly Diagnosed KMT2A-Rearranged AML Leukemia Acute Myeloid Not Yet Recruiting
NCT07639242 Olomorasib + Pembrolizumab KRAS G12C Mutant, PD-L1 TPS 1-49% Locally Advanced or… Lung Cancer Not Yet Recruiting
NCT07685938 Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease Chest Wall Tumor Not Yet Recruiting
NCT07630168 Effects of Infusion Timing on Treatment Response in Solid Tumors Lung Cancer Not Yet Recruiting
See all 120 active UNC Lineberger Comprehensive Cancer Center trials with filters →
Disease Areas
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