InSightec clinical trial pipeline

2 trials changed in the last 30 days: 0 stopped, 2 with notable changes, 0 with minor changes only.

1. Notable

   LIMITLESS · Blood-brain Barrier (BBB) Opening Using Exablate…LIMITLESS · Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

   Primary completion pushed from Jun 1, 2027 to Jun 1, 2031

   Also in this update: Enrollment increased: 30 → 96 participants; Study completion pushed from Dec 1, 2027 to Dec 1, 2031

   InSightec·Phase 3· NCT05317858· Registry history of NCT05317858 on ClinicalTrials.gov (opens the registry)

   Oct 13, 2026

2. Notable

   Blood-Brain Barrier Disruption Using Transcranial MRI-Guided…Blood-Brain Barrier Disruption Using Transcranial MRI-Guided Focused Ultrasound

   Primary endpoint(s) modified

   Also in this update: Results posted: Oct 19, 2026; Trial completed

   InSightec·Not applicable· NCT02343991· Registry history of NCT02343991 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.