H. Lee Moffitt Cancer Center and Research Institute clinical trial pipeline

11 trials changed in the last 30 days: 0 stopped, 6 with notable changes, 5 with minor changes only.

1. Notable

   SRS & Abemaciclib w/wo Imlunestrant · HR+/HER2- Breast CA Brain…SRS & Abemaciclib w/wo Imlunestrant · HR+/HER2- Breast CA Brain Metastases

   Primary completion pushed from Nov 5, 2026 to Jul 2027

   Also in this update: Study completion pushed from Dec 2026 to Dec 2027

   H. Lee Moffitt Cancer Center and Research Institute·Phase 1/2· NCT04923542· Registry history of NCT04923542 on ClinicalTrials.gov (opens the registry)

   Sep 28, 2026

2. Notable

   KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute…KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   Primary and study completion pushed from Nov 15, 2028 to Jul 29, 2031

   H. Lee Moffitt Cancer Center and Research Institute·Phase 2· NCT06144606· Registry history of NCT06144606 on ClinicalTrials.gov (opens the registry)

   Sep 25, 2026

3. Notable

   Genomically Guided Radiation Therapy · Triple Negative Breast…Genomically Guided Radiation Therapy · Triple Negative Breast Cancer

   Primary and study completion pushed from May 2028 to Sep 2029

   H. Lee Moffitt Cancer Center and Research Institute·Phase 2· NCT05528133· Registry history of NCT05528133 on ClinicalTrials.gov (opens the registry)

   Sep 25, 2026

4. Notable

   Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in…Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

   Primary and study completion pushed from Dec 2026 to Aug 2028

   Also in this update: Enrollment closed, study ongoing; Final enrollment: 185 participants (planned 125)

   H. Lee Moffitt Cancer Center and Research Institute·Not specified· NCT05687188· Registry history of NCT05687188 on ClinicalTrials.gov (opens the registry)

   Sep 25, 2026

5. Notable

   Automated Video-Assisted Smoking Treatment · HIV

   Primary endpoint(s) modified

   Also in this update: Results posted: Sep 25, 2026; Enrollment reduced: 638 → 512 participants

   H. Lee Moffitt Cancer Center and Research Institute·Not applicable· NCT05014282· Registry history of NCT05014282 on ClinicalTrials.gov (opens the registry)

   Sep 25, 2026

6. Notable

   Optimizing Cellular and Humoral Immunity by Vaccinating With…Optimizing Cellular and Humoral Immunity by Vaccinating With PCV13 Before and After CAR-T Therapy

   Results posted: Oct 7, 2026

   H. Lee Moffitt Cancer Center and Research Institute·Phase 2· NCT04745559· Registry history of NCT04745559 on ClinicalTrials.gov (opens the registry)

   Oct 7, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.