| Detected | Trial | Change |
|---|---|---|
| 2026-06-11 | NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… |
Trial sites expanded: 286 -> 290 locations |
| 2026-06-11 | NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… |
date change Primary completion pushed: 2028-01-31 -> 2028-09-25 |
| 2026-06-11 | NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… |
date change Completion pushed: 2031-08-31 -> 2032-04-25 |
| 2026-05-29 | NCT06333951 Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced… |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-29 | NCT06333951 Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced… |
Enrollment reduced: 500 -> 49 participants |
| 2026-05-29 | NCT06333951 Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced… |
date change Primary completion moved earlier: 2028-10-27 -> 2026-10-31 |
| 2026-05-29 | NCT06333951 Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced… |
date change Completion moved earlier: 2031-10-27 -> 2026-11-30 |
| 2026-05-15 | NCT05920356 A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum… |
Trial sites expanded: 380 -> 383 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT05920356 | A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum… | Non-Small Cell Lung Cancer (NSCLC) | Recruiting |
| NCT06252649 | Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… | Metastatic Colorectal Cancer | Recruiting |
| NCT06497556 | A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in… | Non-Small Cell Lung Cancer | Active, Not Recruiting |
| NCT04303780 | Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung… | KRAS p, G12c Mutated /Advanced Metastatic NSCLC | Active, Not Recruiting |
| Phase 2 | |||
| NCT05845450 | Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer… | Colorectal Cancer | Recruiting |
| NCT06582771 | A Study of Sotorasib in People With Non-Small Cell Lung Cancer | Non Small Lung Cancer | Recruiting |
| NCT05398094 | Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and… | Non-small Cell Lung Cancer Stage III | Recruiting |
| NCT05118854 | A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin… | Lung Cancer | Recruiting |
| NCT07172919 | A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With… | Advanced Solid Tumors | Recruiting |
| NCT05564377 | Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced… | Advanced Malignant Solid Neoplasm | Recruiting |
| NCT07543172 | CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non… | Advanced Lung Non-Small Cell Carcinoma | Not Yet Recruiting |
| NCT05638295 | Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS… | Advanced Malignant Solid Neoplasm | Active, Not Recruiting |
| Phase 1/2 | |||
| NCT07563738 | A 2-part Phase 1/2 Open-label Trial on ODM-212 | Mesothelioma | Recruiting |
| NCT07012031 | Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally… | Locally Advanced Lung Non-Small Cell Carcinoma | Recruiting |
| NCT03600883 | A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib… | KRAS p.G12C Mutant Advanced Solid Tumors | Active, Not Recruiting |
| Phase 1 | |||
| NCT05815173 | Ladarixin With Sotorasib in Advanced NSCLC | Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation | Recruiting |
| NCT06804824 | A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in… | Advanced Solid Tumors | Recruiting |
| NCT06249282 | Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C… | Advanced Lung Non-Small Cell Carcinoma | Recruiting |
| NCT06892054 | Sotorasib Combined With First-line Chemotherapy for Advanced Pancreatic Adenocarcinoma | Pancreatic Adenocarcinoma | Recruiting |
| NCT06807619 | A Study of Sotorasib in People With Brain Tumors | Brain Tumor | Recruiting |
| NCT06333951 | Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced… | Thoracic Tumors | Active, Not Recruiting |
| Early Phase 1 | |||
| NCT07318389 | ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic… | Dynamic Tumor Resistance | Not Yet Recruiting |