Clinical Trial

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

Recruiting Phase 2
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Record status
This record was last updated March 12, 2026 (before its estimated May 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a window-of-opportunity umbrella platform trial enrolling non-metastatic resectable colorectal patients selected for the presence of a specific targetable molecular alteration. The study aims to test the activity of specific targeted agents/combinations given as a short-course pre-operative strategy, matched with the specific alteration detected, followed by standard of care surgery.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2023-04-26; most recent amendment 2026-03-10.
Status change: Active, Not Recruiting → Recruiting 2023-06-22
Trial Details
NCT Number NCT05845450
Lead Sponsor Gruppo Oncologico del Nord-Ovest
Conditions Colorectal Cancer, Resectable Colorectal Carcinoma
Enrollment 197 participants
Start Date 2023-05-11
Primary Completion 2026-05 (estimated)
Study Completion 2028-05 (estimated)
Updated on ClinicalTrials.gov 2026-03-12