Disease landscape

Endometrial Cancer clinical trials

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451 active trials 271 recruiting 31 Phase 3 276 sponsors 79 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 52 of 79 changes on 20 trials

2026-08-14
Trial terminated
Trial terminated: Following completion of Phase 1b, the Sponsor decided not to initiate Part 2 of the trial.
Primary endpoint(s) modified
Primary completion moved earlier: 2025-07 → 2025-04-30
Completion moved earlier: 2025-11 → 2025-04-30
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants… · NextCure, Inc. · Phase 1/2
2026-07-31
Primary completion pushed: 2026-12 → 2028-01
Enrollment increased: 442 → 542 participants
Trial sites expanded: 79 → 82 locations
Completion pushed: 2027-12 → 2028-06
NCT04657068 A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors · Artios Pharma Ltd · Phase 1/2
2026-08-21
Primary completion pushed: 2026-09-23 → 2027-09-23
Completion pushed: 2026-09-23 → 2027-09-23
NCT04569773 Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer · Memorial Sloan Kettering Cancer Center
2026-08-06
Primary completion pushed: 2027-06-11 → 2028-06-11
Enrollment reduced: 25 → 20 participants
Completion pushed: 2027-06-11 → 2028-06-11
NCT07281547 Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal… · Mayo Clinic · Phase 4
2026-08-04
Primary completion pushed: 2027-04-15 → 2029-04-15
Primary endpoint(s) modified
Completion pushed: 2030-04-15 → 2034-04-15
NCT05603910 Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation… · Aaron Wolfson · Phase 1
2026-08-22
Primary endpoint(s) modified
Recruitment opened
Enrollment increased: 56 → 299 participants
Trial sites expanded: 0 → 3 locations
Primary completion moved earlier: 2028-08 → 2027-08
Trial arms changed: 2 → 3
NCT07623369 A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors · Huahui Health · Phase 1
2026-08-14
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT00514254 Risk Factors for Endometrial Cancer in Black Women · Memorial Sloan Kettering Cancer Center
2026-08-04
Primary completion pushed: 2026-05-29 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-06-30
NCT06096688 Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction · Weill Medical College of Cornell University
2026-07-30
Primary completion pushed: 2026-08-11 → 2027-08-31
Enrollment increased: 1500 → 1700 participants
Completion pushed: 2026-08-11 → 2027-08-31
NCT03538665 The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer… · University of Alabama at Birmingham
2026-08-21
Primary endpoint(s) modified
Trial arms changed: 4 → 5
NCT05269381 Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for… · Mayo Clinic · Phase 1/2
2026-07-31
Primary endpoint(s) modified
Trial completed
Primary completion moved earlier: 2027-10-31 → 2026-02-04
Completion moved earlier: 2027-10-31 → 2026-02-04
NCT01797523 A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients… · M.D. Anderson Cancer Center · Phase 2
2026-08-28
Trial completed
Trial sites expanded: 7 → 10 locations
Primary completion moved earlier: 2025-12-31 → 2024-10-31
Completion moved earlier: 2025-12-31 → 2024-10-31
NCT06014580 Molecular and Epidemiological Characteristics of Endometrial Cancer in Brazil · Latin American Cooperative Oncology Group
2026-08-25
Trial completed
NCT06904365 Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women · Washington University School of Medicine
2026-08-21
Trial completed
Primary completion moved earlier: 2027-05 → 2025-03-06
Completion moved earlier: 2028-05 → 2025-03-06
NCT06339827 ASk Questions in GYnecologic Oncology (ASQ-GYO) · Ira Winer
2026-08-26
Primary completion pushed: 2026-07-01 → 2026-09-01
Completion pushed: 2027-07-01 → 2027-09-01
NCT03668340 AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine… · Dana-Farber Cancer Institute · Phase 2
2026-08-20
Enrollment reopened
NCT04567771 Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for… · Mayo Clinic
2026-08-28
Trial sites reduced: 204 → 199 locations
NCT05611931 Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53… · Karyopharm Therapeutics Inc · Phase 3
2026-08-13
Enrollment closed, study ongoing
NCT06877572 Weight Loss Management in Endometrial Cancer Survivors · University of Kansas Medical Center
2026-08-11
Recruitment opened
Trial sites expanded: 2 → 11 locations
NCT07741968 A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic… · City of Hope Medical Center
2026-08-11
Recruitment opened
NCT06549855 PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd… · Peking University People's Hospital

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-21 NCT07779109 Pelvic Ultra-Hypofractionated Adjuvant Radiotherapy for Endometrial Cancer (PURE-cohort) Instituto de Investigación Sanitaria Aragón new
2026-08-10 NCT07755436 Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and… ArriVent BioPharma, Inc. new Phase 1
2026-08-07 NCT07752875 A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53… LG Chem new Phase 1/2
2026-08-04 NCT07743541 Study of TUB-040 in Patients With Recurrent or Progressive Uterine Cancer After… Tubulis GmbH new Phase 1/2
2026-07-24 NCT07725159 Comparison of Lee-Huang Point and Umbilical Entry for Laparoscopic Success in Endometrial… Dr. Lutfi Kirdar Kartal Training and Research Hospital new
2026-07-20 NCT07714070 Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical… Peking University People's Hospital new Phase 2
2026-07-20 NCT07715747 A Phase I Study to Evaluate the Safety,Pharmacokinetics,Pharmacodynamics,and Efficacy of… TJ Biopharma Co., Ltd. new Phase 1
2026-07-14 NCT07702799 Low-Residue Diet Versus Rectal Enema Before Laparoscopic Surgery for Endometrial Cancer Mahmut Yassa new
2026-07-02 NCT07681414 ctDNA Assessment in Endometrial Cancer for Adjuvant Therapy Guizhou Provincial People's Hospital new
2026-06-30 NCT07675733 A Study of Short-course Hypofractionated Online-adaptive Radiotherapy for the… Royal Marsden NHS Foundation Trust new

Active trials by phase

Early Phase 1
7
Phase 1
70
Phase 1/2
45
Phase 2
94
Phase 2/3
6
Phase 3
25
Phase 4
5
Not charted: 199 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 451

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06726291 Akynzeo as Antiemetic Treatment in Patients With Endometrial Cancer Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Recruiting 2024-12-10
NCT02543710 Biomarker Guided Treatment in Gynaecological Cancer Haukeland University Hospital Recruiting 2017-03-28
NCT07281547 Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal… Mayo Clinic Not Yet Recruiting 2026-08-05
NCT07462663 SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus… Hospital Universitari de Bellvitge Not Yet Recruiting 2026-06-10
NCT06871787 Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses… Istanbul University Not Yet Recruiting 2025-03-14
Phase 3
NCT05256225 Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2… National Cancer Institute (NCI) Recruiting 2026-08-26
NCT07198074 Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin… National Cancer Institute (NCI) Recruiting 2026-08-25
NCT06952504 A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab… Merck Sharp & Dohme LLC Recruiting 2026-08-24
NCT07166094 Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's… Genmab Recruiting 2026-08-17
NCT06989112 DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or… AstraZeneca Recruiting 2026-08-11
NCT07044336 Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial… AstraZeneca Recruiting 2026-07-29
NCT07022483 Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing… Daiichi Sankyo Recruiting 2026-07-28
NCT06340568 A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy… BioNTech SE Recruiting 2026-07-21
NCT03785288 Vaginal Cuff Brachytherapy Fractionation Study Kara Romano, MD Recruiting 2026-04-22
NCT04789694 Prehabilitation in Gynaecological Cancer Patients Charles University, Czech Republic Recruiting 2026-03-19
NCT04073706 Sentinel Node Biopsy in Endometrial Cancer Queensland Centre for Gynaecological Cancer Recruiting 2026-01-30
NCT06712472 Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant… Gustave Roussy, Cancer Campus, Grand Paris Recruiting 2026-01-20
NCT06584032 Study of Fruquintinib Plus Sintilimab for Treatment of Advanced Endometrial Cancer Hutchmed Recruiting 2025-01-07
NCT05611931 Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53… Karyopharm Therapeutics Inc Active, Not Recruiting 2026-08-27
NCT07578649 Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in… Pfizer Not Yet Recruiting 2026-08-17
NCT03914612 Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy… National Cancer Institute (NCI) Active, Not Recruiting 2026-07-31
NCT06486441 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants… Gilead Sciences Active, Not Recruiting 2026-07-29
NCT05078047 Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3… UNICANCER Active, Not Recruiting 2026-07-17
NCT06746116 A Study to Evaluate the Use of Durvalumab in Combination With Platinum-based Chemotherapy… AstraZeneca Active, Not Recruiting 2026-07-17
NCT06132958 Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial… Merck Sharp & Dohme LLC Active, Not Recruiting 2026-04-03
See all 451 active Endometrial Cancer trials with filters →

Top sponsors by active trials in this area

M.D. Anderson Cancer Center (15) · Mayo Clinic (15) · National Cancer Institute (NCI) (15) · AstraZeneca (12) · Memorial Sloan Kettering Cancer Center (12) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (11) · Dana-Farber Cancer Institute (8) · Peking University People's Hospital (7) · Women's Hospital School Of Medicine Zhejiang University (6) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (5)

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