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NCT07779109 · ClinicalTrials.gov record · last posted 2026-08-25

Pelvic Ultra-Hypofractionated Adjuvant Radiotherapy for Endometrial Cancer (PURE-cohort)

Study acronym: PURE-cohort
StatusRecruiting
PhaseNot applicable
Started2026-03-30
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from the ClinicalTrials.gov record
The PURE trial is a prospective multicenter phase II study evaluating the safety and feasibility of ultra-hypofractionated adjuvant pelvic radiotherapy in patients with high-intermediate-risk and high-risk endometrial cancer following surgery. The study investigates a treatment regimen consisting of 27.5 Gy delivered in five fractions using modern image-guided IMRT/VMAT techniques. The primary objective is to assess acute gastrointestinal and genitourinary toxicity according to CTCAE version 5.0.
Trial Details
NCT Number NCT07779109
Lead Sponsor Instituto de Investigación Sanitaria Aragón
Conditions SBRT, Radiation Therapy, Endometrial Cancer, Endometrial Cancer Stage III, High-risk Endometrial Cancer
Enrollment 50 participants
Start Date 2026-03-30
Primary Completion 2030-03-30 (estimated)
Study Completion 2035-03-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-25