Drug Pipeline

Selpercatinib Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
15
Active Studies
3
Recruiting
2
Phase 3
10
Top Sponsors
1
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-05-23 NCT04302025
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages…		 Primary endpoint(s) modified
Active Studies by Phase
Phase 3
2
Phase 2
8
Phase 1/2
2
Early Phase 1
1
Not specified
2
Active Trials
NCT IDTitleConditionStatus
Phase 3
NCT04819100 A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell… Carcinoma, Non-Small-Cell Lung Active, Not Recruiting
NCT04211337 A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid… Medullary Thyroid Cancer Active, Not Recruiting
Phase 2
NCT06563999 Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare… Lung Cancer Stage III Recruiting
NCT04302025 A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages… Non-small Cell Lung Cancer Recruiting
NCT04268550 Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A… Recurrent Lung Non-Small Cell Carcinoma Active, Not Recruiting
NCT04280081 A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including… Solid Tumor Active, Not Recruiting
NCT04589845 Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You… Solid Tumors Active, Not Recruiting
NCT04759911 Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer Malignant Thyroid Gland Neoplasm Active, Not Recruiting
NCT04320888 Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic… Hematopoietic and Lymphatic System Neoplasm Active, Not Recruiting
NCT03155620 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed… Advanced Malignant Solid Neoplasm Active, Not Recruiting
Phase 1/2
NCT03899792 A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or… Medullary Thyroid Cancer Active, Not Recruiting
NCT03157128 A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET… Non-Small Cell Lung Cancer Active, Not Recruiting
Early Phase 1
NCT07146893 Feasibility Study for Repurposing RET Inhibitors Cachexia-Anorexia Syndrome Not Yet Recruiting
Not specified
NCT07419932 Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer Thyroid Cancer Recruiting
NCT07418879 A Real-world Study of Pralsetinib Combined With Leucogen in the Treatment of RET… Non-small Cell Lung Cancer Not Yet Recruiting
Sponsors Running Selpercatinib Trials
Eli Lilly and Company (4) National Cancer Institute (NCI) (2) Loxo Oncology, Inc. (1) SWOG Cancer Research Network (1) Genentech, Inc. (1) Hoffmann-La Roche (1) M.D. Anderson Cancer Center (1) Sun Yat-sen University (1) University of Oklahoma (1) Fudan University (1)
Disease Areas
Non-Small Cell Lung Cancer (NSCLC) (5) Lung Cancer (5) Thyroid Cancer (5) Sarcoma (3) Glioma (2) Non-Hodgkin Lymphoma (2) Colorectal Cancer (1)
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