Disease landscape

Thyroid Cancer clinical trials

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278 active trials 161 recruiting 21 Phase 3 168 sponsors 38 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-20
Primary completion pushed: 2025-12-31 → 2026-12-31
Primary endpoint(s) modified
Trial status changed: Enrolling by Invitation → Recruiting
Completion pushed: 2025-12-31 → 2026-12-31
NCT06931743 The Application of Electrical Stimulation in Postoperative Pain Management of Thyroid… · Xiaonan Huang
2026-08-19
Primary completion pushed: 2026-07-01 → 2026-12-01
Completion pushed: 2026-08-01 → 2027-01-01
NCT07428057 Postoperative Hypocalcemia After Thyroidectomy · Minia University
2026-08-12
Primary completion pushed: 2026-07-15 → 2026-12-15
Completion pushed: 2026-08-15 → 2027-01-15
NCT07059507 Prevalence and Predictors of Incidental Thyroid Carcinoma in Patients With Graves'… · Minia University
2026-08-08
Primary completion pushed: 2025-06-30 → 2025-09-28
Primary endpoint(s) modified
Trial completed
Enrollment increased: 300 → 515 participants
Completion pushed: 2025-06-30 → 2025-10-15
Trial arms changed: 2 → 1
NCT06498674 AI-Assisted Ultrasound Review Before Thyroid Surgery · Fujian Medical University
2026-08-06
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT01412762 Measuring Patient Expectations for Thyroid Surgery · Memorial Sloan Kettering Cancer Center
2026-08-13
Primary endpoint(s) modified
Trial completed
Enrollment increased: 8 → 17 participants
Primary completion moved earlier: 2025-12 → 2023-08-07
Completion moved earlier: 2025-12 → 2023-08-07
NCT02657551 A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid… · Dana-Farber Cancer Institute · Phase 2
2026-08-11
Primary endpoint(s) modified
NCT06738888 Renovated Prediction Model for Difficult Transoral and Submental Endoscopic Thyroidectomy · Shanghai 6th People's Hospital
2026-08-11
Enrollment reduced: 5000 → 874 participants
Trial completed
Completion pushed: 2026-06-30 → 2026-08-04
NCT07255482 Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging… · Brigham and Women's Hospital
2026-08-19
Enrolling by invitation only
NCT07620574 Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored… · Exelixis · Phase 3
2026-08-22
Trial completed
NCT05241834 A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has… · Eli Lilly and Company · Phase 1
2026-08-27
Trial completed
Enrollment increased: 50 → 138 participants
Completion moved earlier: 2025-12-31 → 2025-03-31
NCT05789667 Gender-based Impact on Safety and Efficacy of Lenvatinib in Patients With Differentiated… · Regina Elena Cancer Institute
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07274605 Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy… · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-18
Recruitment opened
NCT07440290 DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult… · Cancer Research UK · Phase 2/3
2026-08-26
Trial sites reduced: 130 → 120 locations
NCT02568267 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors… · Hoffmann-La Roche · Phase 2
2026-08-08
Completion pushed: 2027-11 → 2028-11
NCT04280081 A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including… · Eli Lilly and Company · Phase 2
2026-08-12
Completion pushed: 2026-07 → 2027-07
NCT03215095 RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers · Memorial Sloan Kettering Cancer Center · Early Phase 1
2026-08-09
Trial status changed: Active, Not Recruiting → Unknown
NCT03669432 To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced… · Tata Memorial Hospital
2026-08-09
Trial status changed: Recruiting → Unknown
NCT05989425 Surufatinib as Neoadjuvant Treatment for Locally Advanced or Metastatic Differentiated… · Fudan University · Phase 2
2026-08-02
Trial status changed: Recruiting → Unknown
NCT06520319 Head-to-head Study of 68Ga-MGS5 Versus 68Ga-DOTATATE PET/CT in Patients With Medullary… · First Affiliated Hospital of Fujian Medical University · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-20 NCT07776262 Safety and Efficacy of Cryoablation for Thyroid Tumors Yukun Luo new
2026-07-20 NCT07713901 Database Linkage Study to Evaluate the Risk of Medullary Thyroid Carcinoma Novo Nordisk new
2026-07-15 NCT07704658 Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors Rigel Pharmaceuticals new Phase 4
2026-07-15 NCT07705074 FAPI PET Imaging - An Exploratory Study Martin Huellner new Phase 1/2
2026-07-10 NCT07695974 Clinicopathological Predictors of Recurrence in Papillary Thyroid Carcinoma University of Roma La Sapienza new
2026-07-08 NCT07690839 Pre-Clinic Visit Online Education for Thyroid Cancer Cedars-Sinai Medical Center new
2026-06-22 NCT07661420 211At-MABG in Adults With Advanced Neuroendocrine Cancers University of Pennsylvania new Phase 1
2026-06-22 NCT07659717 Frozen Section-Guided Selective Ipsilateral Central Neck Dissection in Bethesda V-VI… Eleonora Lori, MD new
2026-06-17 NCT07654322 Clinical Study on the Efficacy of Laparoscopic Assisted Open Surgery Through Subclavian… Xijing Hospital new
2026-06-09 NCT07634978 Development and Application of an AI Chatbot for Perioperative Health Education in… Tianjin Medical University Cancer Institute and Hospital new

Active trials by phase

Early Phase 1
6
Phase 1
18
Phase 1/2
12
Phase 2
45
Phase 2/3
6
Phase 3
15
Phase 4
7
Not charted: 169 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 278

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07704658 Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors Rigel Pharmaceuticals Recruiting 2026-08-10
NCT07600580 The Association Between Bilateral Intermediate Cervical Plexus Block During Total… University Hospital Dubrava Recruiting 2026-06-16
NCT06195228 A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of… Fudan University Recruiting 2025-08-14
NCT05830500 Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting 2023-07-25
NCT07354698 Application of Mitoxantrone Hydrochloride Injection in Transoral Robotic Thyroid Cancer… Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Not Yet Recruiting 2026-01-21
NCT01896479 A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic… Exelixis Active, Not Recruiting 2025-09-02
NCT07010393 Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World… Fujian Medical University Not Yet Recruiting 2025-06-08
Phase 3
NCT04290663 Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by… Centre Francois Baclesse Recruiting 2026-06-25
NCT06554652 Selective Neck Dissection Versus Modified Neck Dissection in PTC Fudan University Recruiting 2026-02-27
NCT06558981 Adjuvant Radiotherapy in High Risk Locally Advanced DTC Fudan University Recruiting 2026-02-27
NCT07383246 CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting 2026-02-03
NCT06860971 A Study of AL2846 Capsule Versus Placebo in the Treatment of Advanced… Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting 2025-12-31
NCT05999630 Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With… Vanderbilt University Medical Center Recruiting 2025-10-28
NCT06791005 A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With… Second Affiliated Hospital of Xi'an Jiaotong University Recruiting 2025-01-24
NCT06082180 A Prospective, Open-label, Multicenter, Randomized Controlled Phase III Study of… Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting 2023-10-13
NCT07620574 Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored… Exelixis Enrolling by Invitation 2026-08-18
NCT04940052 Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously… Novartis Pharmaceuticals Active, Not Recruiting 2026-06-26
NCT04211337 A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid… Loxo Oncology, Inc. Active, Not Recruiting 2026-03-19
NCT03570021 ESTIMation of the ABiLity of Prophylactic Central Compartment Neck Dissection to Modify… Gustave Roussy, Cancer Campus, Grand Paris Active, Not Recruiting 2026-03-06
NCT07239674 Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC West China Hospital Not Yet Recruiting 2025-11-20
NCT03690388 A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory… Exelixis Active, Not Recruiting 2025-09-25
NCT01837745 Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk… Gustave Roussy, Cancer Campus, Grand Paris Active, Not Recruiting 2023-05-17
Phase 2/3
NCT07440290 DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult… Cancer Research UK Recruiting 2026-08-17
NCT07444723 Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of… National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Recruiting 2026-06-02
NCT06851663 Trop2-targeted immunoPET Imaging of Solid Tumors RenJi Hospital Recruiting 2026-05-29
See all 278 active Thyroid Cancer trials with filters →

Top sponsors by active trials in this area

Memorial Sloan Kettering Cancer Center (14) · Fudan University (10) · Fujian Medical University (8) · M.D. Anderson Cancer Center (8) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (7) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (5) · West China Hospital (5) · Assiut University (4) · Exelixis (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (4)

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