Clinical Trial

ESTIMation of the ABiLity of Prophylactic Central Compartment Neck Dissection to Modify Outcomes in Low-risk Differentiated Thyroid Cancer

Study acronym: ESTIMABL3
Active, Not Recruiting Phase 3
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Summary
Prospective randomized open phase III non-inferiority trial in cT1bT2N0 papillary thyroid carcinoma comparing: total thyroidectomy alone (experimental group) versus total thyroidectomy + Prophylactic Neck Dissection PND (reference group). Pre-registered patients will be randomized before surgery for tumors with class-6 cytology (Bethesda) or in the operating room after confirmation of malignancy by frozen section analysis for tumors with class-5 cytology.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2018-06-15; most recent amendment 2026-03-05.
Status change: Recruiting → Active, Not Recruiting 2026-03-05
Status change: Not Yet Recruiting → Recruiting 2021-12-20
Trial Details
NCT Number NCT03570021
Lead Sponsor Gustave Roussy, Cancer Campus, Grand Paris
Conditions Thyroid Cancer
Enrollment 352 participants
Start Date 2018-08-08
Primary Completion 2026-12 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-06