Disease landscape

MDS/MPN Overlap clinical trials

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149 active trials 91 recruiting 7 Phase 3 91 sponsors 14 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days

2026-09-25
critical
NCT06071624 Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line… · Huda Salman · Phase 1
2026-09-11
critical
NCT06680661 ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis · Leland Metheny · Phase 2
2026-09-15
critical
NCT04771130 A Study of BGB-11417 in Participants With Myeloid Malignancies · BeOne Medicines · Phase 1/2
2026-09-18
critical
NCT04282187 Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of… · University of Washington · Phase 2
2026-09-17
critical
NCT05807932 Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C… · Heinrich-Heine University, Duesseldorf · Phase 1/2
2026-09-10
critical
NCT06439199 Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the… · Nantes University Hospital
2026-09-29
notable
NCT03418038 Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma… · Mayo Clinic · Phase 2
2026-09-29
minor
NCT03560752 CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants… · City of Hope Medical Center · Phase 1

Active trials by phase

Early Phase 1
3
Phase 1
31
Phase 1/2
28
Phase 2
54
Phase 2/3
2
Phase 3
5
Not charted: 26 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 149

NCT IDTitleSponsorStatusUpdated
Phase 3
NCT06647862 IMM01+Azacitidine VS Placebo +Azacitidine in Patients With Newly Diagnosed Chronic… ImmuneOnco Biopharmaceuticals (Shanghai) Inc. Recruiting 2025-11-25
NCT00843882 Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic… National Cancer Institute (NCI) Active, Not Recruiting 2026-10-01
NCT05153226 GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG DKMS gemeinnützige GmbH Active, Not Recruiting 2026-08-27
NCT05883956 A Study Comparing Treatment Preference Between Oral Decitabine/Cedazuridine and… Otsuka Australia Pharmaceutical Pty Ltd Active, Not Recruiting 2025-03-20
NCT05515029 Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and… Federal Research Institute of Pediatric Hematology, Oncology and Immunology Active, Not Recruiting 2023-09-28
Phase 2/3
NCT04708054 Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With… M.D. Anderson Cancer Center Recruiting 2026-08-11
NCT04256317 A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone… Taiho Oncology, Inc. Recruiting 2026-04-30
Phase 2
NCT06661915 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative… National Cancer Institute (NCI) Recruiting 2026-09-30
NCT03418038 Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma… Mayo Clinic Recruiting 2026-09-28
NCT05564390 MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study… National Cancer Institute (NCI) Recruiting 2026-09-25
NCT05554406 Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed… National Cancer Institute (NCI) Recruiting 2026-09-22
NCT04282187 Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of… University of Washington Recruiting 2026-09-17
NCT03683433 Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute… M.D. Anderson Cancer Center Recruiting 2026-09-14
NCT06566742 A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of… M.D. Anderson Cancer Center Recruiting 2026-09-11
NCT03383575 Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome M.D. Anderson Cancer Center Recruiting 2026-09-04
NCT07249346 Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib… Hannah Choe, MD Recruiting 2026-09-02
NCT07582172 Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as… City of Hope Medical Center Recruiting 2026-08-20
NCT07228624 Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With… Fred Hutchinson Cancer Center Recruiting 2026-08-19
NCT07033598 Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia Theradex Recruiting 2026-08-18
NCT02727803 Personalized NK Cell Therapy in CBT M.D. Anderson Cancer Center Recruiting 2026-07-30
NCT07046078 Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body… Fred Hutchinson Cancer Center Recruiting 2026-07-20
NCT06815003 Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the… City of Hope Medical Center Recruiting 2026-06-29
NCT03314974 Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders Masonic Cancer Center, University of Minnesota Recruiting 2026-06-25
NCT05365035 A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax… M.D. Anderson Cancer Center Recruiting 2026-06-05
NCT05800210 Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in… University of Florida Recruiting 2026-06-04

Top sponsors by active trials in this area

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