Disease landscape

Mantle Cell Lymphoma clinical trials

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212 active trials 109 recruiting 11 Phase 3 126 sponsors 13 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days

2026-09-09
critical
Primary completion pushed: 2026-07-30 → 2029-10
Enrollment reduced: 200 → 160 participants
Completion pushed: 2028-01-30 → 2029-11
NCT06767891 Real-world Study of Acalabrutinib · Ruijin Hospital
2026-08-25
critical
Primary completion pushed: 2026-03-21 → 2027-03
Enrollment closed, study ongoing
NCT05249959 Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in… · Fondazione Italiana Linfomi - ETS · Phase 2
2026-08-21
critical
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2027-08-01 → 2028-08-01
NCT04007029 Modified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or… · Jonsson Comprehensive Cancer Center · Phase 1
2026-08-22
critical
Primary endpoint(s) modified
NCT05006716 A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With… · BeOne Medicines · Phase 1/2
2026-08-26
critical
Primary endpoint(s) modified
NCT04626791 Modified VR-CAP and Acalabrutinib as First Line Therapy for the Treatment of… · Academic and Community Cancer Research United · Phase 2
2026-09-10
notable
Recruitment opened
NCT07225439 Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of… · Paolo Caimi, MD · Phase 1
2026-08-29
minor
Primary completion confirmed: May 2025 (last estimated March 2028)
Completion moved earlier: 2031-09-30 → 2030-03-02
NCT04802590 Study of Ibrutinib + CD20 Antibody and Venetoclax in Patients With Untreated Mantle Cell… · The Lymphoma Academic Research Organisation · Phase 2
2026-09-06
minor
Trial status changed: Active, Not Recruiting → Unknown
NCT00877214 Significance of Duration of Maintenance Therapy With Rituximab in Non-Hodgkin Lymphomas · Jurgen Barth · Phase 3

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-26 NCT07788118 A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell… Second Affiliated Hospital, Zhejiang University, School of Medicine new Phase 1/2
2026-07-22 NCT07719556 Orelabrutinib Combined With Obinutuzumab and Short-Course Venetoclax in Patients With… The First Affiliated Hospital with Nanjing Medical University new Phase 2
2026-07-17 NCT07711327 Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase… Tina Baykaner new
2026-07-13 NCT07697339 HDM2005 Combination Therapy in Relapsed/Refractory Mantle Cell Lymphoma Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. new Phase 1
2026-07-06 NCT07684950 Lisaftoclax Plus Pirtobrutinib in Relapsed or Refractory Mantle Cell Lymphoma After… Henan Cancer Hospital new Phase 2
2026-06-29 NCT07673367 Nemtabrutinib With CAR T Therapy in Relapsed/Refractory Mantle Cell Lymphoma Vanderbilt-Ingram Cancer Center new Phase 2

Active trials by phase

Early Phase 1
1
Phase 1
50
Phase 1/2
34
Phase 2
91
Phase 3
11
Phase 4
1
Not charted: 24 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 212

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07264894 ZSDT for the Treatment of R/R Mantle Cell Lymphoma After BTK Inhibitor Failure: a… Zhengzhou University Not Yet Recruiting 2025-12-04
Phase 3
NCT06742996 A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared… BeOne Medicines Recruiting 2026-09-14
NCT05976763 Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for… Alliance for Clinical Trials in Oncology Recruiting 2026-09-02
NCT01804686 A Long-term Extension Study of PCI-32765 (Ibrutinib) Janssen Research & Development, LLC Recruiting 2026-07-31
NCT07377578 A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With… Guangzhou Lupeng Pharmaceutical Company LTD. Recruiting 2026-02-06
NCT06363994 A Global Phase 3 Study of Orelabrutinib+BR Vs.BR in Pts with TN MCL InnoCare Pharma Inc. Recruiting 2024-12-27
NCT06496308 Bendamustine and Rituximab With or Without Orelabrutinib in MCL Treatment Ruijin Hospital Recruiting 2024-07-11
NCT03267433 Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual… ECOG-ACRIN Cancer Research Group Active, Not Recruiting 2026-09-14
NCT07784101 A Phase 3 Study to Compare the Efficacy of ICP-248 in Combination With Orelabrutinib… Beijing InnoCare Pharma Tech Co., Ltd. Not Yet Recruiting 2026-08-25
NCT02972840 A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously… Acerta Pharma BV Active, Not Recruiting 2026-06-01
NCT04002297 A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With… BeOne Medicines Active, Not Recruiting 2026-05-18
NCT04662255 Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With… Loxo Oncology, Inc. Active, Not Recruiting 2026-05-15
Phase 2
NCT07003295 Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type… National Cancer Institute (NCI) Recruiting 2026-09-09
NCT07029737 A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for… AstraZeneca Recruiting 2026-09-01
NCT07341191 Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma… Canadian Cancer Trials Group Recruiting 2026-08-26
NCT07673367 Nemtabrutinib With CAR T Therapy in Relapsed/Refractory Mantle Cell Lymphoma Vanderbilt-Ingram Cancer Center Recruiting 2026-08-17
NCT07285044 The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home… Mayo Clinic Recruiting 2026-07-30
NCT07272499 Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With… Ruijin Hospital Recruiting 2026-07-28
NCT06252675 Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma University of California, San Francisco Recruiting 2026-07-24
NCT07082686 A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or… Beijing InnoCare Pharma Tech Co., Ltd. Recruiting 2026-07-23
NCT07719556 Orelabrutinib Combined With Obinutuzumab and Short-Course Venetoclax in Patients With… The First Affiliated Hospital with Nanjing Medical University Recruiting 2026-07-22
NCT04792489 DALY II USA/ MB-CART2019.1 for DLBCL Miltenyi Biomedicine GmbH Recruiting 2026-07-13
NCT06558604 Phase II Study of Glofitamab With Venetoclax +/- Zanubrutinib in High-risk Mantle-cell… The Lymphoma Academic Research Organisation Recruiting 2026-07-10
NCT03314974 Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders Masonic Cancer Center, University of Minnesota Recruiting 2026-06-25
NCT07453095 Study With Glofitamab in Patients With MCL and Inadequate Response or Relapse Following… Fondazione Italiana Linfomi - ETS Recruiting 2026-06-25

Top sponsors by active trials in this area

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