Disease landscape

MDS clinical trials

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267 active trials 153 recruiting 28 Phase 3 177 sponsors 33 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-18
critical
Withdrawn before enrolling
Trial withdrawn: FDA requested significant changes to the study protocol
Enrollment reduced: 25 → 0 participants
NCT07387354 Pacritinib With Aza for Upfront Myelodysplastic Syndrome · Thomas Jefferson University · Phase 1/2
2026-08-28
critical
Primary completion pushed: 2025-06 → 2026-03-31
Completion pushed: 2026-12 → 2027-12
NCT05153226 GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG · DKMS gemeinnützige GmbH · Phase 3
2026-08-11
critical
Primary completion pushed: 2025-12 → 2027-12
Primary endpoint(s) modified
Enrollment increased: 40 → 59 participants
Completion pushed: 2026-01 → 2028-01
Trial arms changed: 1 → 3
NCT04608110 A Phase 1 Trial of ASTX030 in Patients With Myelodysplastic Syndrome · Taiho Pharmaceutical Co., Ltd. · Phase 1
2026-08-06
critical
Primary completion pushed: 2026-01-01 → 2027-02-28
Phase changed: not specified → Phase 2/3
Completion pushed: 2027-01-01 → 2027-02-28
NCT06895538 Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic… · Peking University First Hospital · Phase 2/3
2026-08-08
critical
Primary completion pushed: 2026-08-31 → 2030-08-31
Completion pushed: 2026-08-31 → 2030-08-31
NCT05092451 Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in… · M.D. Anderson Cancer Center · Phase 1/2
2026-08-13
critical
Primary completion pushed: 2026-06-22 → 2027-09-30
Completion pushed: 2026-11 → 2027-11
NCT03680677 Frailty Phenotype Assessments to Optimize Treatment Strategies for Older Patients With… · Abramson Cancer Center at Penn Medicine
2026-08-27
critical
Enrollment reduced: 44 → 30 participants
Trial completed
Completion moved earlier: 2027-02 → 2026-06
NCT02494167 Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM) · Baylor College of Medicine · Phase 1
2026-08-21
notable
Enrollment reduced: 37 → 29 participants
Enrollment closed, study ongoing
NCT05796570 A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant… · Franziska Wachter · Phase 2
2026-08-13
notable
Trial completed
Primary completion moved earlier: 2027-01 → 2026-04-15
Completion moved earlier: 2027-01 → 2026-04-15
NCT02942290 A Study Evaluating Venetoclax in Combination With Azacitidine in Participants With… · AbbVie · Phase 1
2026-08-22
minor
Trial sites expanded: 47 → 53 locations
NCT04419649 A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk… · Takeda · Phase 2
2026-08-19
minor
Trial sites expanded: 18 → 22 locations
NCT06656494 ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid… · Beijing InnoCare Pharma Tech Co., Ltd. · Phase 1
2026-08-27
minor
Trial sites expanded: 12 → 17 locations
NCT06717958 Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell… · Technische Universität Dresden · Phase 2
2026-08-05
minor
Completion pushed: 2026-05-25 → 2026-08-14
NCT07052006 A Phase 2a Study of HT-6184 in Subjects With IPSS-R Very Low, Low or Intermediate Risk… · Halia Therapeutics, Inc. · Phase 2
2026-08-07
minor
Primary completion pushed: 2026-07 → 2026-08-24
NCT06670222 Oral Arsenic (ATO) in Low-risk Myelodysplastic Syndromes (MDS) · Groupe Francophone des Myelodysplasies · Phase 1
2026-08-02
minor
Trial status changed: Recruiting → Unknown
NCT04365179 Study of NEROFE, a Novel Hormone-Peptide in Adult Patients With Advanced MDS and AML · Immune System Key Ltd · Phase 1
2026-08-09
minor
Trial status changed: Active, Not Recruiting → Unknown
NCT02061800 CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell… · Diane George · Phase 1/2
2026-08-02
minor
Trial status changed: Not Yet Recruiting → Unknown
NCT06514443 Barriers and Faciliators for Physical Activity in People With RMDs · Anne-Kathrin Rausch

Active trials by phase

Early Phase 1
3
Phase 1
54
Phase 1/2
30
Phase 2
70
Phase 2/3
7
Phase 3
21
Phase 4
1
Not charted: 81 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 267

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05891249 A Study to Evaluate the Safety and Effectiveness of Luspatercept for the Treatment of… Bristol-Myers Squibb Active, Not Recruiting 2025-10-20
Phase 3
NCT04628026 Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients… University of Ulm Recruiting 2026-08-24
NCT06499285 A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk… Takeda Recruiting 2026-08-21
NCT06465953 Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With… Institut de Recherches Internationales Servier Recruiting 2026-08-05
NCT07422480 A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low… Takeda Recruiting 2026-07-22
NCT07702578 A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic… TScan Therapeutics, Inc. Recruiting 2026-07-22
NCT04064060 A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other… Celgene Recruiting 2026-07-01
NCT07396480 Fludarabine Plus Melphalan Versus Addition of Venetoclax to Fludarabine/Melphalan… First Affiliated Hospital of Zhejiang University Recruiting 2026-03-17
NCT07075016 Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly… Stichting Hemato-Oncologie voor Volwassenen Nederland Recruiting 2025-08-19
NCT04184505 Feasibility of Allogeneic Stem Cell Transplantation in Higher-risk-MDS (ACROBAT) Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting 2025-04-29
NCT05153226 GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG DKMS gemeinnützige GmbH Active, Not Recruiting 2026-08-27
NCT07735117 Mitoxantrone Hydrochloride Liposome, Cytarabine, G-CSF Plus Venetoclax vs. Azacitidine… Ruijin Hospital Not Yet Recruiting 2026-07-29
NCT07722988 A Study to Investigate the Efficacy and Safety of Roxadustat (FG-4592) for Treating… Kyntra Bio Not Yet Recruiting 2026-07-23
NCT05949684 ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants… Bristol-Myers Squibb Active, Not Recruiting 2026-06-30
NCT03173248 Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants… Institut de Recherches Internationales Servier Active, Not Recruiting 2026-06-29
NCT07653581 rhTPO + CsA vs CsA in the Treatment of LR-MDS With Thrombocytopenia Peking Union Medical College Hospital Not Yet Recruiting 2026-06-17
NCT04401748 Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change… AbbVie Active, Not Recruiting 2026-05-06
NCT04547049 A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From… First Affiliated Hospital of Zhejiang University Active, Not Recruiting 2026-04-09
NCT06927232 AZA+Lus VS AZA Monotherapy in HR-MDS Peking Union Medical College Hospital Not Yet Recruiting 2025-04-15
NCT03223961 A Trial Testing Early vs Late Onset of EPO Alfa Treatment in Lower Risk MDS Groupe Francophone des Myelodysplasies Active, Not Recruiting 2025-03-11
NCT05674539 Reduced Intensity Conditioning Regimens for Acute Myeloid Leukemia and Myelodysplastic… Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Enrolling by Invitation 2025-02-10
NCT03682536 A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa… Celgene Active, Not Recruiting 2024-11-20
Phase 2/3
NCT04708054 Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With… M.D. Anderson Cancer Center Recruiting 2026-08-11
NCT06895538 Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic… Peking University First Hospital Recruiting 2026-08-05
NCT06972641 Molecular Genetics Guide the Maintenance Therapy After Allogeneic Hematopoietic Stem Cell… Ruijin Hospital Recruiting 2025-05-18

Top sponsors by active trials in this area

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