Disease landscape

HIV clinical trials

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1,194 active trials 569 recruiting 80 Phase 3 438 sponsors 205 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 52 of 205 changes on 20 trials

2026-08-27
Recruitment suspended
Recruitment suspended: Temporarily Closed (Paused) to Accrual and Study Agents/Products
NCT06071767 Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults… · National Institute of Allergy and Infectious Diseases (NIAID) · Phase 1/2
2026-08-20
Withdrawn before enrolling
Trial withdrawn: Study withdrawn prior to participant enrollment due to lack of study product.
Primary completion pushed: 2026-07-31 → 2026-12-31
Enrollment reduced: 27 → 0 participants
Sponsor changed: Weill Medical College of Cornell University → University of California, San Diego
Completion pushed: 2026-07-31 → 2026-12-31
NCT07090174 CASCADE: Testing for Safety and Immune Effects of PDS0101, an Anti-HPV Therapy, Among… · University of California, San Diego · Phase 2
2026-08-21
Reclassified as terminated (was completed)
Trial terminated: Unanticipated changes to Tanzania's government oversight structure led to the premature termination of the trial.
NCT05357144 AmbassADDOrs for Health Study · University of California, San Francisco
2026-08-19
Recruitment suspended
Recruitment suspended: Study was put on pause on July 29, 2026, due to a Grade 5 Serious adverse event
NCT07217379 The DART DELIVER-02 Study · University of North Carolina, Chapel Hill · Phase 1
2026-08-01
Trial terminated
Trial terminated: Recruitment window closed
Enrollment reduced: 40 → 10 participants
Primary completion moved earlier: 2027-03 → 2026-07-01
Completion moved earlier: 2027-03 → 2026-07-01
NCT07466836 The Effects of Chiropractic Care on Inflammation and Quality of Life in People Living… · Tyson Perez, DC, PhD
2026-08-15
Primary completion pushed: 2030-12-30 → 2032-09-14
Recruitment opened
Trial sites expanded: 0 → 4 locations
Completion pushed: 2030-12-30 → 2032-09-14
NCT07393659 A Continued Access Study for Participants Transitioning From ViiV Healthcare-sponsored or… · ViiV Healthcare · Phase 3
2026-08-28
Primary completion pushed: 2026-08-28 → 2027-03-31
Completion pushed: 2027-02-28 → 2027-08-31
NCT05288790 Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT · Vanderbilt University Medical Center · Phase 2
2026-08-27
Primary completion pushed: 2027-01-05 → 2027-07-31
Primary endpoint(s) modified
Completion moved earlier: 2028-01-05 → 2027-07-31
NCT07218211 Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using… · Duke University · Phase 4
2026-08-28
Primary completion pushed: 2023-09-11 → 2027-07-06
Completion pushed: 2026-06 → 2027-07-06
NCT05654883 New York City Observational Study of Mpox Immunity · NYU Langone Health
2026-08-28
Primary completion pushed: 2026-08 → 2026-12
Completion pushed: 2026-08 → 2026-12
NCT05858034 Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus… · Wake Forest University Health Sciences
2026-08-27
Primary completion pushed: 2026-08-15 → 2027-07-31
Recruitment opened
Completion pushed: 2026-08-15 → 2027-07-31
NCT07213258 CHAMPION: Combining HIV And Meth Prevention and Treatment Interventions Optimized for… · University of California, San Diego
2026-08-26
Primary completion pushed: 2026-06-27 → 2027-06-27
Completion pushed: 2026-07-31 → 2027-07-31
NCT03738410 An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS · University of Miami
2026-08-20
Primary completion pushed: 2026-08-31 → 2026-12-31
Completion pushed: 2027-08-31 → 2027-12-31
NCT04949464 Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking… · AIDS Malignancy Consortium
2026-08-25
Primary completion pushed: 2026-05-31 → 2031-05-31
Completion pushed: 2026-05-31 → 2031-05-31
NCT04405700 Measuring Adverse Pregnancy and Newborn Congenital Outcomes · Indiana University
2026-08-15
Primary completion pushed: 2027-10-30 → 2028-03-03
Completion pushed: 2027-10-30 → 2028-03-03
NCT07040319 Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in… · National Institute of Allergy and Infectious Diseases (NIAID) · Phase 1/2
2026-08-14
Primary completion pushed: 2026-08-01 → 2029-08-01
Completion pushed: 2026-08-01 → 2029-08-01
NCT05419024 Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption · National Cancer Institute (NCI) · Phase 2
2026-08-12
Primary completion pushed: 2026-07-30 → 2027-07-30
Completion pushed: 2027-07-30 → 2028-07-30
NCT05470491 Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell… · National Cancer Institute (NCI) · Phase 1/2
2026-08-18
Primary completion pushed: 2026-02 → 2027-03
Enrollment closed, study ongoing
Completion pushed: 2026-07 → 2027-03
NCT06550804 Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention · University of Illinois at Chicago · Phase 3
2026-08-19
Primary completion pushed: 2027-12 → 2028-12
NCT05586581 SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During… · Yale University · Phase 1/2
2026-08-06
Primary completion pushed: 2026-05-01 → 2026-08-09
Enrollment closed, study ongoing
Completion pushed: 2026-11-01 → 2027-08-09
NCT06374758 Accelerated ART Initiation for PWHIV Who Are Out of Care · University of Missouri-Columbia · Phase 4

Active trials by phase

Early Phase 1
10
Phase 1
73
Phase 1/2
33
Phase 2
96
Phase 2/3
16
Phase 3
64
Phase 4
74
Not charted: 828 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,194

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07218211 Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using… Duke University Recruiting 2026-08-26
NCT07476339 REINItiation of Antiretroviral Therapy Using Oral bicTegravir, emtrIcitAbine and… CAN Community Health Recruiting 2026-08-19
NCT07076043 Multi-product PrEP Delivery to Young Women Seeking Reproductive Health Services and… University of Alabama at Birmingham Recruiting 2026-07-22
NCT07678268 Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With… Instituto Mexicano del Seguro Social Recruiting 2026-07-01
NCT05669534 Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP University of Connecticut Recruiting 2026-06-15
NCT06337032 A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have… Gilead Sciences Recruiting 2026-06-10
NCT06485154 Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial University of Witwatersrand, South Africa Recruiting 2026-06-09
NCT05547048 Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice… Yale University Recruiting 2026-06-03
NCT06856174 Menopausal HT for Women Living With HIV (HoT) Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections Recruiting 2026-05-22
NCT06158126 UNCPM 22314 - Pregnancy, Infant and Maternal Health Outcomes Study University of North Carolina, Chapel Hill Recruiting 2026-05-05
NCT06829238 Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV… University of Alabama at Birmingham Recruiting 2026-04-22
NCT06598397 Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable… New York University Recruiting 2026-04-13
NCT05537935 Low Dose Naltrexone for Pain in Patients With HIV Emory University Recruiting 2026-04-09
NCT07199335 Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs Massachusetts General Hospital Recruiting 2026-03-19
NCT05630638 Doravirine Dose Optimisation in Pregnancy University of Liverpool Recruiting 2026-02-19
NCT05495906 A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living With HIV University of British Columbia Recruiting 2026-02-05
NCT06967519 OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa Yale University Recruiting 2026-02-04
NCT07160075 HIV Prevention With PrEP Among People on Opioid Replacement Therapy Cara Spence Recruiting 2025-10-07
NCT06762730 Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in… Hadassah Medical Organization Recruiting 2025-09-18
NCT06967753 Switch to Dolutegravir Plus Lamivudine Dual-Therapy in Transgender Women Living With HIV… UBATEC Recruiting 2025-09-12
NCT04730609 Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery Mayo Clinic Recruiting 2025-09-11
NCT07154849 Comparative Study Between the Efficacy of Intravenous Hydrocortisone and Intravenous… Ain Shams University Recruiting 2025-09-04
NCT07138144 Efficacy, Safety, and ToLerability of Switching to A Two-Drug Regimen With DTG/3TC… José Antonio Mata Marín Recruiting 2025-08-22
NCT06474364 HIV Prevention and Care Interventions for Youth in Uganda MU-JHU CARE Recruiting 2025-07-29
NCT07031063 Safety, Tolerability and Effectiveness of DTG/3TC vs BIC/TAF/FTC in PWH Without… Instituto Mexicano del Seguro Social Recruiting 2025-06-26
See all 1,194 active HIV trials with filters →

Top sponsors by active trials in this area

National Institute of Allergy and Infectious Diseases (NIAID) (45) · University of California, San Francisco (40) · Gilead Sciences (27) · Yale University (27) · Johns Hopkins University (24) · University of Washington (23) · ViiV Healthcare (23) · ANRS, Emerging Infectious Diseases (19) · Boston University (19) · Columbia University (18)

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