Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize HIV prevention content, leading to improvements in HIV prevention information, motivation, behavioral skills, and behaviors (IMB).

NCT Number	NCT05669534
Lead Sponsor	University of Connecticut
Conditions	Hiv, Opioid Use Disorder
Enrollment	256 participants
Start Date	2023-03-01
Primary Completion	2027-01 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-15