Clinical Trial

OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa

Study acronym: OPTIMAH
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
A longitudinal study with four parallel cohorts with each participant followed for 2 years: two cohorts in Busia (high malaria transmission site) and two cohorts in Kampala (low malaria transmission). Each site will have a cohort of children living with HIV (CLHIV) and HIV- uninfected children and will be age-matched, enrolled in parallel, and followed for two years. All children will be enrolled without malaria infection, as determined by a negative blood smear at baseline.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-05-02; most recent amendment 2026-02-02.
Status change: Not Yet Recruiting → Recruiting 2026-02-02
Trial Details
NCT Number NCT06967519
Lead Sponsor Yale University
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions Malaria, Hiv
Enrollment 380 participants
Start Date 2025-12-18
Primary Completion 2027-12 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-04