Sponsor pipeline

Gilead Sciences clinical trial pipeline

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80 active trials 25 recruiting 31 Phase 3 25 disease areas 39 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days showing 36 of 39 changes on 19 trials

2026-09-09
Trial terminated
Trial terminated: Following review of accumulated safety data from DISCOVER and real-world use of F/TAF, the sponsor determined that the...
NCT02842086 Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide… · Phase 3
2026-09-19
Trial terminated
Trial terminated: Sponsor decision, no safety concerns.
Primary completion confirmed: August 2026 (last estimated July 2028)
NCT05718700 Study of Bulevirtide in Participants With Chronic Hepatitis D Infection
2026-09-30
Primary completion pushed: 2026-11 → 2030-07
NCT06532656 Study of Bictegravir/Lenacapavir in Children and Adolescents With HIV-1 · Phase 2/3
2026-09-29
Primary completion pushed: 2029-07 → 2030-09
Completion pushed: 2029-07 → 2030-09
NCT07038447 A Study of KITE-363 in Participants With Refractory Autoimmune Diseases · Phase 1
2026-09-12
Primary completion pushed: 2026-09 → 2027-03
Completion pushed: 2026-09 → 2027-03
NCT05186974 Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With… · Phase 2
2026-09-04
Primary completion pushed: 2026-08 → 2027-03
Final enrollment: 39 participants (planned 100)
Completion pushed: 2026-08 → 2027-03
NCT06727565 Study of Novel Treatment Combination Therapies in Participants With Head and Neck… · Phase 2
2026-09-22
Primary endpoint(s) modified
Enrollment increased: 1000 → 1500 participants
Interventions modified
Trial arms changed: 6 → 11
NCT05041309 Long-Term Follow-Up Study After Gene-Modified Cell Treatment in Kite Studies
2026-09-12
Enrollment closed, study ongoing
Trial sites reduced: 129 → 102 locations
NCT06029972 Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active… · Phase 2
2026-09-18
Enrollment closed, study ongoing
Final enrollment: 304 participants (planned 416)
NCT05007782 Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced… · Phase 1
2026-09-04
Enrollment closed, study ongoing
Final enrollment: 65 participants (planned 75)
NCT06902519 Study of GS-0151 in Participants With Rheumatoid Arthritis · Phase 1
2026-09-29
Interventions modified
Primary completion moved earlier: 2030-07 → 2026-11
NCT06532656 Study of Bictegravir/Lenacapavir in Children and Adolescents With HIV-1 · Phase 2/3
2026-09-09
Primary completion pushed: 2026-07 → 2026-10
Completion pushed: 2026-07 → 2026-10
NCT06539338 A Study to Investigate Safety of INT2104 Infusions in Participants Aged 18 Years of Age… · Phase 1
2026-09-16
Enrollment increased: 318 → 402 participants
Trial arms changed: 2 → 3
NCT06051617 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis · Phase 3
2026-09-26
Trial sites expanded: 28 → 34 locations
NCT04989803 Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell… · Phase 1/2
2026-09-24
Trial sites expanded: 7 → 16 locations
NCT07719491 Study of GS-0415 and How It Works in People With HIV · Phase 1
2026-09-22
Trial sites expanded: 12 → 15 locations
NCT07546812 Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With… · Phase 2
2026-09-10
Trial sites expanded: 356 → 372 locations
NCT05633654 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's… · Phase 3
2026-09-10
Trial sites expanded: 8 → 11 locations
NCT07708727 Study of an Injectable Regimen of GS-3242 With Lenacapavir Compared to Biktarvy in People… · Phase 2/3
2026-09-05
Trial sites expanded: 14 → 19 locations
NCT07479797 Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants… · Phase 3
2026-09-05
Trial sites expanded: 36 → 55 locations
NCT07645287 A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically… · Phase 2

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-09-25 NCT07841977 Study of Seladelpar and Cilofexor in Participants With Primary Biliary Cholangitis Phase 2 Not Yet Recruiting
2026-09-25 NCT07841990 Substudy-01: A Study of Long-Acting HIV-1 Treatments Taken by Mouth in People With HIV-1… Phase 2 Not Yet Recruiting

Active trials by phase

Phase 1
18
Phase 1/2
4
Phase 2
24
Phase 2/3
7
Phase 3
24
Phase 4
1
Not charted: 2 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 80

NCT IDTitleConditionStatusUpdated
Phase 4
NCT06337032 A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have… HIV-1-infection Recruiting 2026-09-09
Phase 3
NCT06051617 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis Primary Biliary Cholangitis Recruiting 2026-09-15
NCT05633654 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's… Triple Negative Breast Cancer Recruiting 2026-09-09
NCT07479797 Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants… Relapsed or Refractory Large B-cell Lymphoma Recruiting 2026-09-04
NCT07682961 Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in… HIV Infections Recruiting 2026-08-14
NCT06801834 Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously… Extensive Stage Small Cell Lung Cancer (ES-SCLC) Recruiting 2026-08-12
NCT07683000 Study of Lenacapavir, Teropavimab, and Zinlirvimab in Virologically Suppressed Adults… HIV-1-infection Recruiting 2026-07-30
NCT07047716 Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP) HIV Pre-exposure Prophylaxis Active, Not Recruiting 2026-08-28
NCT04994509 Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in… Pre-Exposure Prophylaxis of HIV Infection Active, Not Recruiting 2026-08-07
NCT06413498 A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants… Multiple Myeloma Active, Not Recruiting 2026-07-29
NCT06486441 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants… Endometrial Cancer Active, Not Recruiting 2026-07-29
NCT06333808 Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who… HIV-1-infection Active, Not Recruiting 2026-06-15
NCT06630299 Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Standard of Care in… HIV-1-Infection Active, Not Recruiting 2026-05-29
NCT05089734 Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or… Non-Small Cell Lung Cancer Active, Not Recruiting 2026-05-07
NCT03301506 Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC) Primary Biliary Cirrhosis Active, Not Recruiting 2026-05-04
NCT06630286 Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With… HIV-1-infection Active, Not Recruiting 2026-04-30
NCT05605899 Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line… High-risk Large B-cell Lymphoma (LBCL) Active, Not Recruiting 2026-04-15
NCT05382299 Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients… Triple Negative Breast Cancer Active, Not Recruiting 2026-04-06
NCT04639986 Asian Study of Sacituzumab Govitecan (IMMU-132) in HR+/HER2- Metastatic Breast Cancer… Metastatic Breast Cancer Active, Not Recruiting 2026-02-09
NCT01651403 Study to Evaluate the Antiviral Efficacy, Safety and Tolerability of Tenofovir Disoproxil… Chronic Hepatitis B Active, Not Recruiting 2026-01-30
NCT05502237 Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With… Non-small Cell Lung Cancer Active, Not Recruiting 2026-01-30
NCT04925752 Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV… Pre-Exposure Prophylaxis of HIV Infection Active, Not Recruiting 2025-12-23
NCT05371093 Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With… Relapsed/Refractory Follicular Lymphoma Active, Not Recruiting 2025-10-15
NCT05840211 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With… Locally Advanced or Unresectable Metastatic Breast Cancer Active, Not Recruiting 2025-10-03
NCT05382286 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's… Triple Negative Breast Cancer Active, Not Recruiting 2025-09-18
See all 80 active Gilead Sciences trials with filters →

Disease areas by active trials, top 10 of 25

Breast Cancer (8) · Lung Cancer (6) · Triple-Negative Breast Cancer (6) · Non-Hodgkin Lymphoma (5) · Non-Small Cell Lung Cancer (NSCLC) (5) · DLBCL (3) · Multiple Myeloma (3) · Acute Lymphoblastic Leukemia (ALL) (2) · Bladder Cancer (2) · Leukemia (2)

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