Disease landscape

COPD clinical trials

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727 active trials 389 recruiting 32 Phase 3 447 sponsors 82 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 50 of 82 changes on 20 trials

2026-08-28
Trial terminated
Trial terminated: This study shall be terminated as a result of strategic adjustments to the company-sponsored research and development o...
Enrollment reduced: 57 → 33 participants
Primary completion moved earlier: 2026-10 → 2026-08-21
Completion moved earlier: 2026-12 → 2026-08-21
NCT07267130 A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of… · Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd. · Phase 1
2026-08-22
Primary completion pushed: 2025-08 → 2026-04-30
Trial completed
Completion pushed: 2025-11 → 2026-06-30
NCT05641207 A Clinical Evaluation of the RheOx Bronchial Rheoplasty System · Energenx Medical LTD.
2026-08-28
Primary completion pushed: 2029-03-31 → 2029-06-30
Trial status changed: Recruiting → Not Yet Recruiting
Completion moved earlier: 2030-04-30 → 2029-12-31
NCT07477600 cfMSC Stem Cell Therapy Targeting COPD · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-12
Primary completion pushed: 2026-06-30 → 2026-09-30
Enrollment closed, study ongoing
Trial sites reduced: 118 → 110 locations
Completion pushed: 2026-10-31 → 2027-02-01
NCT06496620 A Study to Evaluate Solrikitug in Participants With COPD (ZION) · Uniquity One (UNI) · Phase 2
2026-08-13
Primary completion pushed: 2027-02 → 2027-10
Enrollment increased: 90 → 105 participants
Completion pushed: 2027-02 → 2027-10
Trial arms changed: 8 → 10
NCT07285122 Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With… · Atisama Therapeutics · Phase 1
2026-08-27
Primary completion pushed: 2026-05-12 → 2026-12-12
Completion pushed: 2026-05-12 → 2027-12-12
NCT07031336 Photon-counting CT in Chest Imaging · Duke University
2026-08-22
Primary completion pushed: 2025-11-20 → 2026-05-20
Enrollment reduced: 40 → 28 participants
Trial completed
Completion pushed: 2025-12-15 → 2026-06-01
NCT06891677 Internet-Based Cognitive Behavioral Therapy and Educational Program for People Living… · Jonas Agholme
2026-08-18
Primary completion pushed: 2025-12-01 → 2026-12-01
Completion pushed: 2025-12-01 → 2026-12-01
NCT07133880 Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting… · University of Tennessee Graduate School of Medicine · Phase 4
2026-08-15
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2027-08-01 → 2027-11-01
NCT05502653 Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV · University of Pittsburgh
2026-08-11
Primary completion pushed: 2042-02 → 2042-12-31
Completion pushed: 2042-02 → 2042-12-31
NCT02800499 KOrea COpd Subgroup Registry and Subtype Research · Konkuk University Medical Center
2026-08-07
Primary completion pushed: 2026-06 → 2026-12
Completion pushed: 2026-10 → 2027-02
NCT05879211 Goal Concordant Care Learning Laboratory · Duke University
2026-08-04
Primary endpoint(s) modified
Trial completed
Completion pushed: 2023-03-30 → 2023-06-01
NCT04655170 Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and… · University of Tennessee Graduate School of Medicine · Phase 4
2026-08-08
Primary endpoint(s) modified
Primary completion moved earlier: 2018-11-10 → 2018-10-11
Completion pushed: 2025-02 → 2027-11
NCT01728571 LungVITamin D and OmegA-3 Trial (lungVITAL) · Brigham and Women's Hospital
2026-08-28
Enrollment reduced: 111 → 89 participants
Trial completed
NCT07353034 Functional Social Support in COPD Self-Management · Medical University of South Carolina
2026-08-28
Recruitment opened
NCT07705737 Rademikibart IV for Acute Asthma and COPD Exacerbation · Connect Biopharm LLC · Phase 2
2026-08-19
Recruitment opened
NCT07668518 A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of KIT2014 in Patients… · Kither Biotech Srl · Phase 1/2
2026-08-19
Recruitment opened
NCT07640451 A Clinical Trial to Evaluate the Efficacy and Safety of HRS-9821 Inhalation Suspension in… · Guangdong Hengrui Pharmaceutical Co., Ltd · Phase 2
2026-08-15
Enrollment closed, study ongoing
Trial sites reduced: 486 → 481 locations
Primary completion moved earlier: 2034-07-01 → 2027-06-30
Completion moved earlier: 2034-07-01 → 2027-06-30
NCT05878769 A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic… · Hoffmann-La Roche · Phase 3
2026-08-04
Recruitment opened
NCT07725939 A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in… · UCB Biopharma SRL · Phase 2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07114120 Clinical Study on the Treatment of Stable Bronchiectasis With Bailing Capsules Combined… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07790627 Effect of Utilizing Virtual Reality With Pulmonary Rehabilitation on Depression in COPD… Imam Abdulrahman Bin Faisal University new
2026-08-26 NCT07788092 Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An… Azienda Ospedaliera di Perugia new
2026-08-25 NCT07785375 Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD… Hospital del Mar Research Institute (IMIM) new
2026-08-25 NCT07786220 Cognitive Load and Inhaler Technique in COPD Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara new
2026-08-21 NCT07780656 A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared… GlaxoSmithKline new Phase 3
2026-08-21 NCT07780669 A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared… GlaxoSmithKline new Phase 3
2026-08-19 NCT07773194 Progressive Muscle Relaxation and Deep Breathing Exercises in Patients With COPD Firat University new
2026-08-12 NCT07759245 A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic… Eli Lilly new Phase 2
2026-08-07 NCT07751705 Induced Sputum Collection in COPD Patients With and Without a Vibroacoustic Device Fraunhofer-Institute of Toxicology and Experimental Medicine new
2026-08-07 NCT07752420 Effects of Structural Integration on Chest Wall Expansion Among COPD Patients Green International University new

Active trials by phase

Early Phase 1
2
Phase 1
16
Phase 1/2
10
Phase 2
46
Phase 2/3
4
Phase 3
28
Phase 4
27
Not charted: 594 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 727

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07073950 A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate… AstraZeneca Recruiting 2026-08-24
NCT06531798 Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian… AstraZeneca Recruiting 2026-08-20
NCT07133880 Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting… University of Tennessee Graduate School of Medicine Recruiting 2026-08-17
NCT07192016 129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With… Western University, Canada Recruiting 2026-07-31
NCT06334575 Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD… Maria Joyera Rodríguez Recruiting 2026-07-20
NCT07053423 A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants… Sanofi Recruiting 2026-06-12
NCT06892210 Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive… Copenhagen Respiratory Research Recruiting 2026-03-18
NCT07135427 Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency University of Alabama at Birmingham Recruiting 2025-11-10
NCT07114120 Clinical Study on the Treatment of Stable Bronchiectasis With Bailing Capsules Combined… Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting 2025-08-11
NCT05703919 Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease Central Denmark Region Recruiting 2025-06-10
NCT06825013 Bronchodilators and Lung Mechanics During Exercise in COPD Dr. J. Alberto Neder Recruiting 2025-02-13
NCT06571942 Effect of the Inhaled Triple Therapies Over the Small Airway in Biomass Exposure National Institute of Respiratory Diseases, Mexico Recruiting 2024-08-26
NCT05772013 Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations Dr Ian B Wilkinson Recruiting 2024-04-03
NCT07721922 Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs… University of Tennessee Graduate School of Medicine Not Yet Recruiting 2026-08-17
NCT06152653 The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM) University of California, San Francisco Active, Not Recruiting 2026-08-13
NCT07749001 Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab Western University, Canada Not Yet Recruiting 2026-08-06
NCT07587658 This After Market Study is Seeing if Dupilumab Plus Usual Standard of Care (SOC) is… Regeneron Pharmaceuticals Not Yet Recruiting 2026-05-14
NCT04238221 Effect of add-on Doxofylline on Lung Function in Stable COPD University of Milan Not Yet Recruiting 2026-04-29
NCT04789057 Atorvastatin Effect on Reduction of COPD Exacerbations Medical University of Bialystok Active, Not Recruiting 2026-04-21
NCT07508644 RSV Vaccination to Reduce Recurrent AECOPD Chinese University of Hong Kong Not Yet Recruiting 2026-04-13
NCT07362173 Actualities in Procedural Sedation: Remimazolam Iuliu Hatieganu University of Medicine and Pharmacy Active, Not Recruiting 2026-03-25
NCT07011225 Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein… Federal University of São Paulo Active, Not Recruiting 2025-06-08
NCT06991426 Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD… Federal University of São Paulo Not Yet Recruiting 2025-05-28
NCT06929767 Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary… Ottawa Hospital Research Institute Not Yet Recruiting 2025-04-16
NCT06552364 Air Pollution and Inhaled Corticosteroids in COPD University of British Columbia Not Yet Recruiting 2025-03-27
See all 727 active COPD trials with filters →

Top sponsors by active trials in this area

AstraZeneca (17) · Assiut University (15) · Henan University of Traditional Chinese Medicine (11) · Riphah International University (11) · VA Office of Research and Development (10) · China-Japan Friendship Hospital (9) · Assistance Publique - Hôpitaux de Paris (7) · Sanofi (7) · ADIR Association (6) · Hacettepe University (6)

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