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Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab

Study acronym: ADORE
StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
Western University, Canada
58 trials monitored
See 2 trials at risk
COPD
1,119 trials monitored
See 34 trials at risk
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests. The study will evaluate the response to this medication after 24 and 48 weeks of treatment. The main questions it aims to answer are: 1. Does mepolizumab improve ventilation defect percent as measured on 129-Xenon MRI in adults with COPD. 2. Does mepolizumab improve the amount of mucus plugs in the lungs as measured by lung CT in adults with COPD. Participants will: 1. Take mepolizumab by subcutaneous injection every 4 weeks for the duration of the study. 2. Visit Robarts 4 times over 48 weeks for tests and imaging.
Trial Details
NCT Number NCT07749001
Lead Sponsor Western University, Canada
Conditions
(from sponsor)		 COPD (Chronic Obstructive Pulmonary Disease)
Related terms Pulmonary Disease, Chronic Obstructive
Enrollment 36 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov