Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

Study acronym: STOP-COPD
StatusRecruiting
PhasePhase 4
Started

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Trial flagged as At Risk
Primary completion moved at least 9 months later May 31, 2027 → Feb 29, 2028
See other at-risk trials from Central Denmark Region

Record History

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  1. Primary completion pushed from May 31, 2027 to Feb 29, 2028
    • Eligibility criteria expanded, about 10 words
    • Secondary endpoints: details revised at 13 of 18 entries
    • Publications: details revised at 1 of 1 entry
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Jun 1, 2025 to Jun 2, 2025
    • Site details revised
    v8
  3. Start date: May 1, 2025 to Jun 1, 2025v7 Show 4 more changesShow less
    • Primary completion date: Mar 30, 2027 to May 31, 2027
    • Study completion date: Mar 30, 2028 to May 31, 2028
    • Secondary endpoints: details revised at 18 of 18 entries
    • Study description expanded, about 214 words
  4. Start date: Apr 1, 2025 to May 1, 2025v6
  5. Start date: Mar 1, 2025 to Apr 1, 2025
    • Study sites: 0 to 1
    v5
Show 3 earlier versionsHide 3 earlier versions
  1. Primary completion date: Sep 30, 2025 to Mar 30, 2027
    • Start date: Oct 1, 2023 to Mar 1, 2025
    • Study completion date: Jan 8, 2026 to Mar 30, 2028
    v4
  2. Start date: May 2023 to Oct 1, 2023v3
  3. Secondary endpoints revised (18)
    • Eligibility criteria expanded, about 3 words
    v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Central Denmark Region
3 trials monitored
See 1 trial at risk
COPD
1,120 trials monitored
See 36 trials at risk
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
Trial Details
NCT Number NCT05703919
Lead Sponsor Central Denmark Region
Conditions
(from sponsor)		 COPD Exacerbation, COPD Exacerbation Acute
Related terms Pulmonary Disease, Chronic Obstructive
Enrollment 1,888 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov