Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality

The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years). The main question it aims to answer is to test the non-inferiority advice of a moderate alcohol drinking pattern on all-cause mortality and other chronic disease like cardiovascular disease, cancer or type 2 diabetes. Participants will receive during 4 years an advice to drink alcohol following a Mediterranean Alcohol Drinking Pattern (MADP): consuming alcohol in moderation, avoidance of binge drinking and preference for red wine. Researchers will compare those who will receive a MADP advice with those who will receive an advice on abstention to see if the advice on MADP is not inferior than the abstention advice to prevent all-cause mortality and other chronic diseases.

NCT Number	NCT06338215
Lead Sponsor	Clinica Universidad de Navarra, Universidad de Navarra
Conditions	All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis, Type 2 Diabetes, Depression, Dementia, Injury Traumatic +2 more
Enrollment	10,000 participants
Start Date	2024-05-15
Primary Completion	2028-06-30 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2024-12-12