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The Jackson Heart Study of Cardiovascular Disease Among African Americans

Study acronym: JHS
StatusActive, Not Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 9, 2025 (before its estimated August 12, 2025 completion). Its status may not reflect the trial's current state.

Amendment history

  1. Minor

    Publications: details revised at 2 of 11 entries

    Study Status, Oversight, Referencesv12

  2. Minor

    Trial status: Enrolling by Invitation to Active, Not Recruiting

    Enrollment target: estimated 3000 to confirmed 5306; Study description shortened, about 61 words

    Show what changed: Study description
    [...] ortionate burden of cardiovascular disease (CVD) in African AmericansAmerican adults. In addition, the JHS conducts community education and outr [...] math enrichment programs to prepare and encourage students from underrepresented racial/ethnic groups to pursue biomedical careers. The study recruited 5306 African- American residentsadults living in the Jackson, MS, metropolitan statistical area of (Hinds, Madison, and Rankin Counties). Participants were enrolled from each of 4 recruitment pool [...] bers, 22%. Recruitment was limited to non-institutionalized adult African AmericansAmerican adults aged 35- [...] [...]

    Study Status, Oversight, Study Description, Study Design, Eligibility, IPDSharingv11

  3. Minor

    Primary and study completion dates: Apr 12, 2025 to Aug 12, 2025

    Study Statusv10

  4. Notable

    Primary and study completion dates: Apr 12, 2023 to Apr 12, 2025

    Study description shortened, about 12 words

    Show what changed: Study description
    [...] portionate burden of cardiovascular disease (CVD) in African- Americans. In addition, the JHS conducts community educatio [...] ience and math enrichment programs to prepare and encourage students from underrepresented minorityracial/ethnic studentsgroups to pursue biomedical careers. The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities study, to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professi [...] . The study recruited 5 [...] [...]

    Study Status, Study Descriptionv9

  5. Notable

    Trial status: Suspended to Enrolling by Invitation

    Enrollment target: 5306 to 3000; Primary and study completion dates: Aug 2024 to Apr 12, 2023; Start date: Sep 2000 to Sep 19, 2000; and 1 more

    Show all 5 changes in this update
    • Notable Trial status: Suspended to Enrolling by Invitation
    • Notable Enrollment target: 5306 to 3000
    • Notable Primary and study completion dates: Aug 2024 to Apr 12, 2023
    • Minor Start date: Sep 2000 to Sep 19, 2000
    • Minor Study site revised
      Show what changed
      UniversityUMMC, ofJSU, MississippiTougaloo MedicalCollege, Center Department of MedicineMSDH

    Study Status, Conditions, Study Design, Contacts/Locationsv8

Show 6 earlier versions

  1. Stopped

    Trial status: Active, Not Recruiting to Suspended

    Sponsor's reason: COVID-19 outbreak

    Study sites: 3 to 1; Study description shortened, about 4 words

    Show what changed: Study description
    The Jackson Heart Study (JHS) https://www.jacksonheartstudy.org/jhsinfo/, initiated in 1998, is a longitudinal investigation of geneti [...] represented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/), to broaden data collection in an African- American populat [...]

    Study Identification, Study Status, Oversight, Study Description, Outcome Measures, Contacts/Locations, IPDSharingv7

  2. Minor

    Primary and study completion dates: Aug 2024

    Study description shortened, about 37 words; Study title revised

    Show what changed: Study description
    BACKGROUND: Heart disease and stroke remain the first and third leading killers of all Americans, with a disproportionate share of the burden borne by African Americans. Cardiovascular and total mortality are known to be higher among African Americans than among white Americans, but reasons for thes [...] The Jackson Heart Study (JHS) initialhttps://www.jacksonheartstudy.org/jhsinfo/, initiated examinationin 1998, whichis begana longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addi [...] [...]
    Show what changed: Study title
    The Jackson Heart Study (JHS) of Cardiovascular DiseasesDisease inAmong African Americans

    Study Identification, Study Status, Study Description, Contacts/Locations, IPDSharingv6

  3. Notable

    Start date: Oct 1996 to Sep 2000

    Trial status: Recruiting to Active, Not Recruiting; Enrollment target: estimated 5307 to confirmed 5306; Study sites: 1 to 3; and 2 more

    Show all 6 changes in this update
    • Notable Start date: Oct 1996 to Sep 2000
    • Minor Trial status: Recruiting to Active, Not Recruiting
    • Minor Enrollment target: estimated 5307 to confirmed 5306
    • Minor Study sites: 1 to 3
    • Minor Eligibility criteria expanded, about 7 words
      Show what changed
      Inclusion Criteria: African American Residents of Jackson, Mississippi Exclusion Criteria: Institutionalization
    • Minor Study title shortened, about 1 word
      Show what changed
      EnvironmentalJackson andHeart GeneticStudy Factors(JHS) That Influenceof Cardiovascular DiseaseDiseases in African Americans

    Study Identification, Study Status, Sponsor/Collaborators, Oversight, Study Design, Eligibility, Contacts/Locations, IPDSharing, Referencesv5

  4. Minor

    Study description expanded, about 2 words

    Site contact updated; Publications: 10 to 11

    Show what changed: Study description
    [...] r risk factors, such as elevated total cholesterol, reduced high-density lipoprotein (HDL)-cholesterol, and heavy cigarette smoking, are more common i [...]
    Show what changed: Publications
    Sempos CT, Bild DE, Manolio TA. Overview of the Jackson Heart Study: a study of cardiovascular diseases in African American men and women. Am J Med Sci. 1999 Mar;317(3):142-6. doi: 10.1097/00000441-199903000-00002.

    Study Status, Study Description, Study Design, Contacts/Locations, Referencesv4

  5. Minor

    Enrollment target: 5307

    Completion date: May 2013 to not stated; Eligibility criteria expanded, about 1 word; Study description shortened, about 69 words; and 1 more

    Show all 5 changes in this update
    • Minor Enrollment target: 5307
    • Minor Completion date: May 2013 to not stated
    • Minor Eligibility criteria expanded, about 1 word
      Show what changed
      NoInclusion eligibilityCriteria: African criteriaAmerican
    • Minor Study description shortened, about 69 words
      Show what changed
      [...] . Cardiovascular and total mortality are known to be higher inamong BlackAfrican Americans than among white Americans, but reasons for these differences remain to be definedunknown. In addition, well-documented declines in cardiovascularCVD and coronary disease mortality in the past three decades have not been shared equally between Blacksblacks and whites; age. Age-adjusted death rates were identical in both groups in 1980, but by 1994 the rate among African Americans was 14 percent% higher than in whites. The race difference in magnitude of [...] lity is greater in women than men and higher in mid [...]
    • Minor Study title expanded, about 7 words
      Show what changed
      JacksonEnvironmental Heartand StudyGenetic (JHS)Factors That Influence Cardiovascular Disease in African Americans

    Study Identification, Study Status, Study Description, Study Design, Eligibilityv3

  6. Minor

    Study Status

    Re-verified, no change to tracked fields

    v2

  1. Minor

    Study First Submitted

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
National Heart, Lung, and Blood Institute (NHLBI)
135 trials monitored
See 12 trials at risk
Stroke
3,289 trials monitored
See 142 trials at risk
Heart Disease
2,136 trials monitored
See 109 trials at risk
Hypertension
1,795 trials monitored
See 85 trials at risk
and 1 more disease
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the University of Mississippi Medical Center), NIMHD, and NHLBI.
Trial Details
NCT Number NCT00005485
Lead Sponsor National Heart, Lung, and Blood Institute (NHLBI)
Collaborators: National Institute on Minority Health and Health Disparities (NIMHD)
Conditions Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease, Hypertension, Cerebrovascular Disorders
Enrollment 5,306 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov