Population Health Research Institute clinical trial pipeline

5 trials changed in the last 30 days: 0 stopped, 4 with notable changes, 1 with a minor change only.

1. Notable

   SAFE · Surgical Ablation of AF Efficacy Trial

   Primary completion pushed from Sep 30, 2026 to Sep 30, 2027

   Also in this update: Completion pushed from Dec 31, 2026 to Dec 31, 2027

   Population Health Research Institute·Not applicable· NCT05434819· Registry history of NCT05434819 on ClinicalTrials.gov (opens the registry)

   Updated Oct 5, 2026

2. Notable

   LIMIT · Low INR to Minimize Bleeding With Mechanical Valves Trial

   Primary and study completion pushed from Dec 31, 2026 to Dec 31, 2028

   Also in this update: Trial sites expanded: 35 → 45 locations

   Population Health Research Institute·Phase 3· NCT03636295· Registry history of NCT03636295 on ClinicalTrials.gov (opens the registry)

   Updated Sep 17, 2026

3. Notable

   HoBIT · Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)

   Primary completion pushed from Sep 2028 to Apr 2029

   Also in this update: Recruitment opened; Completion pushed from Dec 2028 to May 2029

   Population Health Research Institute·Not applicable· NCT07367633· Registry history of NCT07367633 on ClinicalTrials.gov (opens the registry)

   Updated Sep 18, 2026

4. Notable

   LEAST · Glucagon-like Peptide-1 Receptor Agonists for…LEAST · Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy

   Primary endpoint(s) modified

   Also in this update: Enrollment reduced: 826 → 100 participants; Phase changed: Phase 3 → Phase 2

   Population Health Research Institute·Phase 2· NCT07511543· Registry history of NCT07511543 on ClinicalTrials.gov (opens the registry)

   Updated Sep 14, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.