Merck KGaA (Germany) clinical trial pipeline

7 trials changed in the last 30 days: 1 stopped, 1 with a notable change, 5 with minor changes only.

1. Stopped

   (SAD) of M5542 in Healthy Participants

   Recruitment suspended

   Also in this update: Primary completion pushed from Nov 16, 2026 to Dec 18, 2027; Study completion pushed from Mar 18, 2027 to Dec 18, 2027

   Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany·Phase 1· NCT06577337· Registry history of NCT06577337 on ClinicalTrials.gov (opens the registry)

   Oct 20, 2026

2. Notable

   Probenecid on the Pharmacokinetics of Mirdametinib and Its…Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants

   Recruitment opened

   Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany·Phase 1· NCT07840612· Registry history of NCT07840612 on ClinicalTrials.gov (opens the registry)

   Oct 9, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.