Genmab clinical trial pipeline

10 trials changed in the last 30 days: 1 stopped, 3 with notable changes, 6 with minor changes only.

1. Stopped

   GEN1046 as a Single Agent or in Combination With Pembrolizumab…GEN1046 as a Single Agent or in Combination With Pembrolizumab · Recurrent (Non-small Cell) Lung Cancer

   Trial terminated

   Genmab·Phase 2· NCT05117242· Registry history of NCT05117242 on ClinicalTrials.gov (opens the registry)

   Sep 21, 2026

2. Notable

   RAINFOL-01 · Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184)…RAINFOL-01 · Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

   Primary endpoint(s) modified

   Also in this update: Interventions modified; Trial arms changed: 4 → 5

   Genmab·Phase 1/2· NCT05579366· Registry history of NCT05579366 on ClinicalTrials.gov (opens the registry)

   Oct 7, 2026

3. Notable

   Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab…Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2)

   Start date pushed from Sep 15, 2026 to Oct 15, 2026

   Also in this update: Trial sites expanded: 1 → 4 locations; and 1 more change in the last 30 days

   Genmab·Phase 3· NCT07775287· Registry history of NCT07775287 on ClinicalTrials.gov (opens the registry)

   Oct 6, 2026

4. Notable

   Acasunlimab Alone and With Pembrolizumab · Advanced Melanoma of the…Acasunlimab Alone and With Pembrolizumab · Advanced Melanoma of the Skin That Has Returned After Treatment With an Approved Checkpoint Inhibitor Therapy (ABBIL1TY MELANOMA-07)

   Results posted: Sep 30, 2026

   Genmab·Phase 2· NCT06984328· Registry history of NCT06984328 on ClinicalTrials.gov (opens the registry)

   Sep 30, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.