| Detected | Trial | Change |
|---|---|---|
| 2026-08-13 | NCT05875168 First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors |
Trial sites expanded: 33 -> 36 locations |
| 2026-08-11 | NCT07681882 First-in-Human Trial of DS1025a in Participants With Advanced Solid Tumors |
Recruitment opened |
| 2026-08-08 | NCT07474649 A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without… |
Trial sites expanded: 0 -> 12 locations |
| 2026-08-06 | NCT06330064 A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects… |
Phase changed: Phase 2 -> Phase 1/2 |
| 2026-08-06 | NCT06330064 A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects… |
Primary endpoint(s) modified |
| 2026-08-06 | NCT06330064 A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects… |
Enrollment increased: 520 -> 680 participants |
| 2026-08-06 | NCT06330064 A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects… |
Trial arms changed: 13 -> 14 |
| 2026-08-06 | NCT06203210 A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With… |
Primary endpoint(s) modified |
| 2026-08-06 | NCT06203210 A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With… |
Trial sites reduced: 232 -> 229 locations |
| 2026-08-06 | NCT06203210 A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With… |
date change Primary completion pushed: 2027-04-30 -> 2028-01-30 |
| 2026-08-06 | NCT06203210 A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With… |
date change Completion pushed: 2029-02-22 -> 2029-12-01 |
| 2026-08-05 | NCT06644781 A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic… |
Trial sites expanded: 88 -> 132 locations |
| 2026-08-01 | NCT07206472 A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in… |
Enrollment reopened |
| 2026-08-01 | NCT07206472 A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in… |
Enrollment reduced: 2560 -> 2120 participants |
| 2026-08-01 | NCT07206472 A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in… |
Trial sites expanded: 1 -> 23 locations |
| 2026-08-01 | NCT07206472 A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in… |
date change Primary completion pushed: 2028-09-01 -> 2028-11-22 |
| 2026-08-01 | NCT07206472 A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in… |
date change Completion moved earlier: 2029-03-01 -> 2028-12-31 |
| 2026-07-29 | NCT06161025 A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade… |
Trial sites expanded: 152 -> 164 locations |
| 2026-07-29 | NCT03030066 Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas |
Trial completed |
| 2026-07-29 | NCT03030066 Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas |
date change Completion moved earlier: 2026-08-31 -> 2026-07-16 |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-07-31 | NCT07739966 A Study of DS-3939a in Participants With Solid Tumors | Phase 1/2 | Not Yet Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06174987 | A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s) | Advanced Cancer | Recruiting |
| NCT05950945 | Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone… | Breast Cancer | Recruiting |
| NCT06819007 | Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for… | Ovarian Cancer | Recruiting |
| NCT06899126 | Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in… | Non-small Cell Lung Cancer | Recruiting |
| NCT07022483 | Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing… | Endometrial Cancer | Recruiting |
| NCT06644781 | A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic… | Esophageal Squamous Cell Carcinoma | Recruiting |
| NCT06203210 | A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With… | Small Cell Lung Cancer | Recruiting |
| NCT06731478 | Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic… | Gastric Cancer | Recruiting |
| NCT05338970 | HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in… | Nonsquamous Non-small Cell Lung Cancer | Active, Not Recruiting |
| NCT03734029 | Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer… | Breast Cancer | Active, Not Recruiting |
| NCT03529110 | DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive… | Breast Cancer | Active, Not Recruiting |
| NCT04622319 | A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in… | HER2-Positive Primary Breast Cancer | Active, Not Recruiting |
| NCT04704934 | Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or… | Gastric Cancer, Adenocarcinoma | Active, Not Recruiting |
| NCT05215340 | Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment… | Metastatic Non Small Cell Lung Cancer | Active, Not Recruiting |
| NCT05555732 | Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy… | Metastatic Non Small Cell Lung Cancer | Active, Not Recruiting |
| NCT06578247 | Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD… | Leukemia | Active, Not Recruiting |
| NCT07683754 | T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line… | Advanced Breast Cancer | Not Yet Recruiting |
| NCT04656652 | Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small… | Non-small Cell Lung Cancer | Active, Not Recruiting |
| NCT07474649 | A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without… | Coronary Atherosclerosis | Not Yet Recruiting |
| Phase 2/3 | |||
| NCT07129993 | Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus… | Urothelial Cancer | Recruiting |
| NCT06161025 | A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade… | Solid Cancer | Recruiting |
| Phase 2 | |||
| NCT06824168 | Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid… | Acute Myeloid Leukemia | Recruiting |
| NCT06172478 | A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors | Advanced Solid Tumor | Recruiting |
| NCT05280470 | Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung… | Extensive-stage Small-cell Lung Cancer | Active, Not Recruiting |
| NCT06660654 | A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors… | Advanced Solid Tumor | Active, Not Recruiting |