Drug Pipeline

Berzosertib Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
13
Active Studies
0
Recruiting
2
Top Sponsors
Active Studies by Phase
Phase 2
4
Phase 1/2
4
Phase 1
5
Active Trials
NCT IDTitleConditionStatus
Phase 2
NCT02595892 Gemcitabine Hydrochloride Alone or With M6620 in Treating Patients With Recurrent… Ovarian Serous Tumor Active, Not Recruiting
NCT03641313 Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or… Clinical Stage III Gastric Cancer AJCC v8 Active, Not Recruiting
NCT03517969 M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic… Castration-Resistant Prostate Carcinoma Active, Not Recruiting
NCT03896503 Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung… Extensive Stage Lung Small Cell Carcinoma Active, Not Recruiting
Phase 1/2
NCT04802174 Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and… SCLC Active, Not Recruiting
NCT04216316 Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual… Lung Non-Small Cell Squamous Carcinoma Active, Not Recruiting
NCT04826341 A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer… HRD Cancer Active, Not Recruiting
NCT04266912 Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid… Metastatic Malignant Solid Neoplasm Active, Not Recruiting
Phase 1
NCT02627443 Carboplatin, Gemcitabine Hydrochloride, and Berzosertib in Treating Patients With… Metastatic Fallopian Tube Carcinoma Active, Not Recruiting
NCT02589522 Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation… Metastatic Lung Neuroendocrine Neoplasm Active, Not Recruiting
NCT02595931 M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are… Metastatic Colorectal Carcinoma Active, Not Recruiting
NCT04052555 Testing the Addition of an Anti-cancer Drug, Berzosertib, to the Usual Treatment… Bilateral Breast Carcinoma Active, Not Recruiting
NCT02567422 Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation… Head and Neck Carcinoma of Unknown Primary Active, Not Recruiting
Sponsors Running Berzosertib Trials
National Cancer Institute (NCI) (12) M.D. Anderson Cancer Center (1)
Disease Areas
Small Cell Lung Cancer (5) Lung Cancer (3) Non-Small Cell Lung Cancer (NSCLC) (2) Ovarian Cancer (2) Head & Neck Cancer (1) Colorectal Cancer (1) Pancreatic Cancer (1) Prostate Cancer (1) Gastric Cancer (1) Breast Cancer (1)
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