Drug Pipeline

Aflibercept Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
35
Active Studies
16
Recruiting
16
Phase 3
10
Top Sponsors
6
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-09 NCT07501052
Study of the SCD411 Prefilled Syringe for Treating Adults With Wet Age-Related Macular…
overall status: "Not Yet Recruiting" → "Completed"
2026-06-04 NCT07449936
COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901…
Trial sites expanded: 46 -> 65 locations
2026-06-04 NCT07449923
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901…
Trial sites expanded: 48 -> 62 locations
2026-05-21 NCT07482176
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With…
Trial sites expanded: 36 -> 46 locations
2026-05-20 NCT07359456
Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic…
date change Primary completion pushed: 2028-03 -> 2029-08
2026-05-20 NCT07359456
Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic…
date change Completion pushed: 2032-03 -> 2033-08
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-11 NCT07640997 Real-world Study of Aflibercept 8 mg in nAMD Recruiting
2026-05-29 NCT07614776 A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA®… Phase 3 Not Yet Recruiting
Active Studies by Phase
Phase 4
1
Phase 3
14
Phase 2/3
2
Phase 2
2
Phase 1/2
2
Phase 1
3
Not specified
11
Active Trials — top 25 of 35
NCT IDTitleConditionStatus
Phase 4
NCT07118670 High Dose Eylea for Proliferative Diabetic Retinopathy Outcomes Proliferative Diabetic Retinopathy (PDR) Active, Not Recruiting
Phase 3
NCT07389980 Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose… Polypoidal Choroidal Vasculopathy Recruiting
NCT07317934 Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related… Neovascular Age-Related Macular Degeneration (nAMD) Recruiting
NCT05407636 Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD AMD Recruiting
NCT07489131 Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With… Diabetic Macular Edema Recruiting
NCT03803553 Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer Metastatic Colon Cancer Recruiting
NCT07482176 Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With… Neovascular Age-Related Macular Degeneration (nAMD) Recruiting
NCT07449923 CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901… Diabetic Macular Edema Recruiting
NCT07449936 COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901… Diabetic Macular Edema Recruiting
NCT07489586 A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related… Neovascular Age-Related Macular Degeneration (nAMD) Not Yet Recruiting
NCT06556368 A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp… Wet Age-related Macular Degeneration Active, Not Recruiting
NCT06668064 A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)… Wet Age Related Macular Degeneration Active, Not Recruiting
NCT06683742 A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)… Wet Age Related Macular Degeneration Active, Not Recruiting
NCT06856577 Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With… Neovascular Age-Related Macular Degeneration (nAMD) Active, Not Recruiting
NCT07614776 A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA®… Neovascular Age-related Macular Degeneration Not Yet Recruiting
Phase 2/3
NCT07440225 A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) Macular Degeneration Recruiting
NCT07496567 A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) Macular Degeneration Recruiting
Phase 2
NCT07359456 Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic… Metastatic Colorectal Cancer Not Yet Recruiting
NCT04587128 Early-Line Anti-EGFR Therapy to Facilitate Retreatment for Select Patients With mCRC Metastatic Colorectal Cancer Active, Not Recruiting
Phase 1/2
NCT06047379 Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma… Diffuse Astrocytoma, IDH-Mutant Recruiting
NCT06850922 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603… Diabetic Macular Edema Active, Not Recruiting
Phase 1
NCT07567235 Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis Radiation-Induced Skin Fibrosis Recruiting
NCT06817343 A Long-term Follow up Study of EXG102-031 in Patients With wAMD (Everest LTFU) Neovascular Age-Related Macular Degeneration (nAMD) Active, Not Recruiting
NCT02298959 Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced… Clinical Stage IV Cutaneous Melanoma AJCC v8 Active, Not Recruiting
Not specified
NCT06315556 An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a… Retinopathy of Prematurity Recruiting
Sponsors Running Aflibercept Trials
Disease Areas
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