Disease landscape

Schizophrenia clinical trials

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465 active trials 272 recruiting 38 Phase 3 269 sponsors 60 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 41 of 60 changes on 20 trials

2026-08-26
Primary completion pushed: 2026-12 → 2027-09-30
Completion pushed: 2026-12 → 2027-12-31
NCT02639702 Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia · Centre for Addiction and Mental Health · Phase 4
2026-08-15
Primary completion pushed: 2025-12 → 2026-10
Enrollment closed, study ongoing
Completion pushed: 2025-12 → 2026-10
NCT06105151 Study of the Safety, Tolerability, Pharmacokinetics and Food Effects of VV119 Capsules in… · Vigonvita Life Sciences · Phase 1
2026-08-15
Primary completion pushed: 2026-07-01 → 2026-10-01
Completion pushed: 2026-07-01 → 2026-10-01
NCT06504290 Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119 · Vigonvita Life Sciences · Phase 1
2026-08-28
Primary completion pushed: 2026-03-31 → 2026-09
Enrollment closed, study ongoing
Completion pushed: 2026-03-31 → 2026-09
NCT05435300 Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia · Centre for Addiction and Mental Health
2026-08-26
Primary completion pushed: 2026-03-31 → 2027-03
Enrollment closed, study ongoing
Completion pushed: 2026-03-31 → 2027-03
NCT04033679 The Effects of Non-invasive Brain Stimulation on Treatment Adherence in Schizophrenia · Centre for Addiction and Mental Health
2026-08-13
Primary completion pushed: 2026-12-31 → 2027-12-31
Primary endpoint(s) modified
Completion pushed: 2026-12-31 → 2027-12-31
NCT07408934 A Trial of Group Cognitive Behavioral Therapy for Psychosis (the Feeling Safe Programme) · The Royal Ottawa Mental Health Centre
2026-08-28
Enrollment reduced: 26 → 15 participants
Trial completed
Completion moved earlier: 2025-12 → 2025-02-14
NCT05017532 Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders · Douglas Mental Health University Institute
2026-08-28
Enrollment reduced: 390 → 192 participants
Trial completed
Primary completion moved earlier: 2029-08-31 → 2026-07-31
Completion moved earlier: 2029-08-31 → 2026-07-31
NCT05661448 Promoting Cognitive Health in Schizophrenia · Douglas Mental Health University Institute
2026-08-21
Enrollment reduced: 200 → 135 participants
Trial completed
Primary completion moved earlier: 2025-12-31 → 2025-11-25
Completion moved earlier: 2026-05-31 → 2025-12-16
NCT05929352 Song-making In a Group (SING) · Yale University
2026-08-01
Trial completed
Trial sites reduced: 175 → 94 locations
NCT05304767 An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in… · Karuna Therapeutics, Inc., a Bristol Myers Squibb company · Phase 3
2026-08-05
Recruitment opened
NCT07734493 A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia · Leal Therapeutics, Inc · Phase 1
2026-08-20
Recruitment opened
NCT06898879 Enhancing Veteran-Clinical Collaboration in VA PRRCs · VA Office of Research and Development
2026-08-25
Completed without a posted recruiting period
Primary completion pushed: 2026-03-31 → 2026-06-15
NCT07374588 Impact of Medication Education on Adherence and Side Effects · Cumhuriyet University
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07479758 Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in… · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-22
Recruitment opened
Enrollment increased: 62 → 74 participants
NCT07658898 dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia · Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
2026-08-18
Enrollment closed, study ongoing
NCT06881810 Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to… · Central Institute of Mental Health, Mannheim · Phase 2
2026-08-21
Recruitment opened
NCT07146802 Personalized Metacognitive Training for Psychosis: A Randomized Controlled Trial · University Hospital, Strasbourg, France
2026-08-21
Recruitment opened
NCT06817980 Disorders of the Sense of Self and Physical Activity · University Hospital, Strasbourg, France
2026-08-21
Trial completed
NCT04916626 The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With… · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
2026-08-18
Recruitment opened
NCT07006935 REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community… · Case Western Reserve University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-24 NCT07781007 Effectiveness of a Board Game Intervention on Cognitive and Functional Outcomes in Older… Kaohsiung Kai-Suan Psychiatric Hospital new
2026-08-24 NCT07782034 40-Hz Audiovisual Stimulation in Schizophrenia Spectrum Disorders National Cheng Kung University new
2026-08-19 NCT07773831 Efficacy and Safety of Temporal Interference Stimulation in Treatment-Resistant… Zhimin Wang new
2026-08-12 NCT07759895 Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in… Amit Lotan new Phase 2
2026-08-10 NCT07755605 Digital Therapeutics for Social Cognitive Function in Schizophrenia Spectrum Disorder Samsung Medical Center new
2026-08-05 NCT07748078 Snoezelen Therapy in Adults With Alcohol Dependence and Adults With Schizophrenia The Jerzy Kukuczka Academy of Physical Education in Katowice new
2026-07-29 NCT07734493 A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia Leal Therapeutics, Inc new Phase 1
2026-07-23 NCT07722728 A Study to Investigate Pharmacokinetics, Safety, and Tolerability of B2227… Bostal Drug Delivery Co., Ltd new Phase 2/3
2026-07-20 NCT07713849 Transition Care for FEP University of Chicago new
2026-07-16 NCT07708402 Healing Stigma Through Stories National Yang Ming Chiao Tung University new

Active trials by phase

Early Phase 1
4
Phase 1
18
Phase 1/2
11
Phase 2
36
Phase 2/3
4
Phase 3
34
Phase 4
22
Not charted: 336 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 465

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT02639702 Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia Centre for Addiction and Mental Health Recruiting 2026-08-25
NCT06562608 Anticholinergic Deprescription in Schizophrenia Deepak K. Sarpal, M.D. Recruiting 2026-07-10
NCT07105111 A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive… Neurocrine Biosciences Recruiting 2026-06-16
NCT04113993 Bazedoxifene -Treatment for Women With Schizophrenia The Alfred Recruiting 2026-06-03
NCT05823532 Anti-Inflammatory Challenge in Schizophrenia Emory University Recruiting 2026-06-03
NCT07221877 A Study to Evaluate the Effect of KarXT on Urological Safety Bristol-Myers Squibb Recruiting 2026-06-03
NCT06174116 Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With… University of Massachusetts, Worcester Recruiting 2026-05-22
NCT04580134 CLOZAPINE Response in Biotype-1 University of Texas Southwestern Medical Center Recruiting 2026-05-11
NCT05208190 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial New York State Psychiatric Institute Recruiting 2026-05-04
NCT04478838 "Extended" (Alternate Day) Antipsychotic Dosing Centre for Addiction and Mental Health Recruiting 2026-04-13
NCT05316883 Biomarkers in Clozapine-responding Schizophrenia Jimmi Nielsen Recruiting 2026-01-20
NCT05958875 The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared… Dr. Inge Winter Recruiting 2025-09-26
NCT05648591 Safety and Tolerability of Open-Labeled Iloperidone in Adolescents Vanda Pharmaceuticals Recruiting 2025-03-04
NCT03495024 Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological… Corporal Michael J. Crescenz VA Medical Center Recruiting 2019-03-22
NCT07615075 Clinical Trial of an IL-23 Inhibitor for Immune Activation in Clinical Trial of an IL-23… University of Maryland, Baltimore Not Yet Recruiting 2026-05-29
NCT07047651 Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Dr. Stavroula Rakitzi Active, Not Recruiting 2026-05-01
NCT07075237 Efficacy and Functional Recovery After Switching From Paliperidone Palmitate Injection to… Jiangsu Province Nanjing Brain Hospital Not Yet Recruiting 2025-09-29
NCT03575000 Bromocriptine for Patients With Schizophrenia and Prediabetes VA Pittsburgh Healthcare System Not Yet Recruiting 2025-09-22
NCT07153835 Efficacy and Safety of Paliperidone in Schizophrenia - Bangladesh Study Sher-E-Bangla Medical College Not Yet Recruiting 2025-09-04
NCT06923891 An Open-Label Study to Evaluate the Efficacy and Tolerability of Xanomeline/Trospium In… Vanguard Research Group Not Yet Recruiting 2025-04-11
NCT06924255 An 8-week Open-label Study of an Accelerated and Slower Switching to Xanomeline/Trospium… Collaborative Neuroscience Research, LLC Not Yet Recruiting 2025-04-11
NCT04892199 Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic… Anders Fink-Jensen, MD, DMSci Active, Not Recruiting 2024-09-25
Phase 3
NCT05303064 Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects… Alkermes, Inc. Recruiting 2026-08-14
NCT06229210 Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia… Intra-Cellular Therapies, Inc. Recruiting 2026-08-13
NCT07288567 A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia… Bristol-Myers Squibb Recruiting 2026-08-13
See all 465 active Schizophrenia trials with filters →

Top sponsors by active trials in this area

Centre for Addiction and Mental Health (12) · Shanghai Mental Health Center (12) · Central South University (9) · Bristol-Myers Squibb (8) · China Medical University Hospital (8) · The University of Texas Health Science Center, Houston (8) · University Hospital, Strasbourg, France (7) · VA Office of Research and Development (7) · Hôpital le Vinatier (6) · Neurocrine Biosciences (6)

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