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NCT05435300 · ClinicalTrials.gov record · last posted 2026-08-27

Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia

StatusActive, Not Recruiting
PhaseNot specified
Started2021-09-17
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from the ClinicalTrials.gov record
This study will examine changes in synaptic density with transcranial direct current stimulation (tDCS) in the brains of patients with schizophrenia. Synaptic density levels will be measured using a novel positron emission tomography (PET) radiotracer \[18F\]SDM-8, which is currently the best-in-class method to quantify synaptic density in humans. This will be a companion study to a parent study by our group examining the effects of tDCS on treatment adherence in schizophrenia (REB #103-2018).

Protocol amendment history 3 changes detected by DataLookout

2026-08-28
Enrollment closed, study ongoing
2026-08-28
Primary completion pushed: 2026-03-31 → 2026-09
2026-08-28
Completion pushed: 2026-03-31 → 2026-09
Trial Details
NCT Number NCT05435300
Lead Sponsor Centre for Addiction and Mental Health
Conditions Schizophrenia, Schizoaffective
Enrollment 20 participants
Start Date 2021-09-17
Primary Completion 2026-09 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2026-08-27