Eligibility criteria+2 characters
Inclusion Criteria:
Men or women, 18-4555 years of age with a primary diagnosis of Diagnostic and Sta [...] lling and able to give written informed consent;
Plasma CRP 3mg≥2 mg/L;
Significant motivational deficit as reflected by a score [...]
Secondary endpoints14 to 10 entries
Changes in Performance on the Effort Expenditure for Reward Task
Changes in Quality-of-Life Enjoyment and Satisfaction Questionnaire Short Form
Changes in The Calgary Depression Scale for Schizophrenia (CDSS)
Changes in WHO Disability Assessment Schedule (WHODAS)
Primary endpoints4 to 5 entries
Changes in Performance on the Effort Expenditure for Reward Task (EEfRT)
Study description-311 characters
This research project will explore negative symptoms of schizophrenia, such as motivational deficits, by examining the relationship between inflammation and reward-related brain regions.
To accomplish this, we will administer a single infusion of either the anti-inflammatory medication infliximab or [...] Schizophrenia is a chronic and disabling mental illness that affects over 20 million people globally.
One of its most debilitating aspects is a group of symptoms known as negative symptoms, which include reduced motivation, pleasure, and social engagement.
Among these, amotivation-or the lack of dri [...] [...]
Study sitesdetails revised at 1 of 2 sites