Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT06562608 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial
NCT06562608 · ClinicalTrials.gov record · last posted 2026-07-10

Anticholinergic Deprescription in Schizophrenia

StatusRecruiting
PhasePhase 4
Started2025-02-01
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be randomized to either staying on their anticholinergic drugs or undergoing deprescription per routine clinical care, and will undergo follow-up evaluations across 6 months. The investigators predict that reducing and deprescribing these drug, if clinically determined to be unnecessary will will enhance functioning, neurocognition

Amendment record 5 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 5 times since 2024-08-16; most recent amendment 2026-07-09. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2025-02-05
Status change Not Yet Recruiting→Recruitingv3
Trial Details
NCT Number NCT06562608
Lead Sponsor Deepak K. Sarpal, M.D.
Collaborators: National Institute of Mental Health (NIMH)
Conditions Schizophrenia, Schizoaffective Disorder
Enrollment 105 participants
Start Date 2025-02-01
Primary Completion 2028-12-31 (estimated)
Study Completion 2029-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-10