Disease landscape

Newly Diagnosed Multiple Myeloma clinical trials

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83 active trials 40 recruiting 29 Phase 3 58 sponsors 10 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-18
critical
Primary endpoint(s) modified
Recruitment opened
NCT07285239 Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for… · PrECOG, LLC. · Phase 3
2026-08-21
notable
Trial completed
Completion moved earlier: 2026-05-07 → 2026-03-16
NCT04151667 Daratumumab Based Response Adapted Therapy for Older Adults With Newly Diagnosed Multiple… · H. Lee Moffitt Cancer Center and Research Institute · Phase 2
2026-08-18
notable
Enrollment closed, study ongoing
NCT06216158 Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly… · University of Heidelberg Medical Center · Phase 3
2026-08-08
notable
Recruitment opened
NCT07409454 MRD-Guided BCMA/CD3 Bispecific Antibody Treatment After Stem Cell Transplant for Newly… · Institute of Hematology & Blood Diseases Hospital, China · Phase 2
2026-08-25
minor
Trial sites expanded: 127 → 139 locations
NCT05623020 A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and… · Pfizer · Phase 3
2026-08-19
notable
Enrollment increased: 28 → 150 participants
NCT06376526 IMMUNOPLANT for Newly Diagnosed Multiple Myeloma · Dickran Kazandjian, MD · Phase 2
2026-08-09
minor
Trial status changed: Active, Not Recruiting → Unknown
NCT03942224 Daratumumab, Ixazomib, & Dexamethasone or Daratumumab, Bortezomib, & Dexamethasone in… · Emory University · Phase 2
2026-08-02
minor
Trial status changed: Recruiting → Unknown
NCT06109233 A Perspective Study of the MRD-tailored Therapy in Patients With Newly Diagnosed Multiple… · FengYan Jin

Active trials by phase

Early Phase 1
2
Phase 1
7
Phase 1/2
7
Phase 2
28
Phase 2/3
3
Phase 3
26
Phase 4
2
Not charted: 8 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 83

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06409702 Treatment of High-risk Newly Diagnosed Multiple Myeloma With Minimal Residual Disease… The First Affiliated Hospital of Soochow University Recruiting 2025-06-12
NCT07709884 A Single-center, Prospective, Single-arm Clinical Study Exploring the Treatment of Newly… The First Affiliated Hospital of Soochow University Not Yet Recruiting 2026-07-17
Phase 3
NCT05623020 A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and… Pfizer Recruiting 2026-08-24
NCT04566328 Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple… ECOG-ACRIN Cancer Research Group Recruiting 2026-08-19
NCT07285239 Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for… PrECOG, LLC. Recruiting 2026-08-17
NCT07764978 Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT AstraZeneca Recruiting 2026-08-14
NCT05552222 A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and… Janssen Research & Development, LLC Recruiting 2026-07-06
NCT05558319 NDMM Patients Candidates for ASCT Comparing Extended VRD Plus vs. Isa-VRD vs… PETHEMA Foundation Recruiting 2026-06-25
NCT05561387 Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a… SWOG Cancer Research Network Recruiting 2026-06-10
NCT05243797 Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone… European Myeloma Network B.V. Recruiting 2026-06-04
NCT06679101 A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and… GlaxoSmithKline Recruiting 2026-04-22
NCT07297329 A Study to Evaluate the Safety and Efficacy of SCTC21C in Combination With Bortezomib… Sinocelltech Ltd. Recruiting 2026-01-29
NCT00602641 Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly… National Cancer Institute (NCI) Active, Not Recruiting 2026-08-27
NCT06216158 Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly… University of Heidelberg Medical Center Active, Not Recruiting 2026-08-17
NCT07735637 A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared… AstraZeneca Not Yet Recruiting 2026-07-30
NCT04483739 Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem… European Myeloma Network B.V. Active, Not Recruiting 2026-07-16
NCT04923893 A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a… Janssen Research & Development, LLC Active, Not Recruiting 2026-07-06
NCT05827016 A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy… Bristol-Myers Squibb Active, Not Recruiting 2026-07-02
NCT07624513 Determination 2 - Isatuximab, Iberdomide, Bortezomib and Dexamethasone Induction… Dana-Farber Cancer Institute Not Yet Recruiting 2026-06-03
NCT03319667 A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib… Sanofi Active, Not Recruiting 2026-05-04
NCT05317416 Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple… Pfizer Active, Not Recruiting 2026-04-16
NCT05257083 A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by… Stichting European Myeloma Network Active, Not Recruiting 2026-03-17
NCT06045806 A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide… Celgene Active, Not Recruiting 2026-03-05
NCT03729804 Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide and… University of Chicago Active, Not Recruiting 2026-03-04
NCT01863550 Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With… ECOG-ACRIN Cancer Research Group Active, Not Recruiting 2025-09-08

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