Disease landscape

Major Depressive Disorder clinical trials

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590 active trials 334 recruiting 51 Phase 3 368 sponsors 96 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 44 of 96 changes on 20 trials

2026-08-28
Withdrawn before enrolling
Trial withdrawn: unable to obtain equipment needed for study
Enrollment reduced: 25 → 0 participants
NCT07553364 Auditory Stimulation for Insomnia and Depression · Wake Forest University Health Sciences
2026-07-31
Trial terminated
Trial terminated: Funding withdrawn by sponsor.
Primary completion moved earlier: 2027-12 → 2026-07-15
Completion moved earlier: 2028-04 → 2026-07-15
NCT06843187 Lemborexant for the Treatment of Residual Insomnia in Major Depressive Disorder (MDD) · Unity Health Toronto · Phase 2
2026-08-25
Primary completion pushed: 2027-12 → 2029-01
Primary endpoint(s) modified
Completion pushed: 2028-01 → 2029-03
NCT07282678 Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major… · Pulvinar Neuro, LLC
2026-08-28
Primary completion pushed: 2026-06-30 → 2027-07-01
Completion pushed: 2026-07-31 → 2027-09-30
NCT05895747 5-HTP and Creatine for Depression R33 Phase · University of Utah · Phase 2
2026-08-26
Primary completion pushed: 2025-07 → 2026-08-01
Enrollment closed, study ongoing
Completion pushed: 2025-08 → 2026-09-01
NCT05028738 Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and… · University of British Columbia
2026-08-13
Primary completion pushed: 2026-07-01 → 2026-10-01
Completion pushed: 2026-11-01 → 2026-12-01
NCT06529029 Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral… · Michigan State University · Phase 2/3
2026-08-20
Primary completion pushed: 2026-06-30 → 2027-07-31
Completion pushed: 2026-06-30 → 2027-07-31
NCT06093906 Positive Processes and Transition to Health (PATH) · Case Western Reserve University
2026-08-20
Primary completion pushed: 2026-09 → 2027-09
Completion pushed: 2026-09 → 2027-12
NCT06523439 Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents · University of Texas at Austin
2026-08-04
Primary completion pushed: 2028-05-01 → 2028-10-01
Completion pushed: 2028-05-01 → 2028-10-01
NCT07139106 Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal… · New York State Psychiatric Institute · Phase 4
2026-08-04
Primary completion pushed: 2026-07-31 → 2027-03-31
Completion pushed: 2026-07-31 → 2027-03-31
NCT06795451 Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential… · University of Cincinnati · Phase 1/2
2026-08-18
Primary completion pushed: 2026-04 → 2027-04
Completion pushed: 2027-04 → 2027-07
NCT05613972 Integrated Suicide & Trauma Therapy for Suicide Risk · Unity Health Toronto
2026-08-18
Primary completion pushed: 2026-03-30 → 2027-03-30
Primary endpoint(s) modified
Recruitment opened
Completion pushed: 2026-10-01 → 2027-10-01
NCT07185451 Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) Combined With… · First Affiliated Hospital of Chongqing Medical University
2026-08-12
Primary completion pushed: 2027-06-30 → 2027-12-31
Completion pushed: 2027-10-31 → 2027-12-31
NCT04556890 Pain and Major Depressive Disorder · University of California, Los Angeles
2026-08-08
Primary completion pushed: 2027-10-01 → 2028-01
Primary endpoint(s) modified
Completion pushed: 2027-10-01 → 2028-01
NCT07376018 Ketogenic Diet and Neuromodulation in Treatment Resistant Depression · Sunnybrook Health Sciences Centre
2026-07-31
Primary completion pushed: 2026-06-01 → 2027-06-01
Completion pushed: 2026-08-31 → 2027-08-31
NCT05966532 Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older… · University of Texas Southwestern Medical Center
2026-08-28
Primary endpoint(s) modified
NCT07783633 Identifying Biomarkers of Response to Digital Interventions for Mood Disorders · Centre for Addiction and Mental Health
2026-08-27
Primary endpoint(s) modified
NCT07383467 No Time to Wait: Single Session Intervention · United Christian Hospital
2026-07-31
Primary endpoint(s) modified
NCT07728253 Probiotic IBNI617 for Moderate to Severe Depression · IBIOME BIOTECHNOLOGY CO., LTD
2026-08-18
Primary endpoint(s) modified
Recruitment opened
NCT07203144 Selenium Supplementation for Improving Depression in Children and Adolescents: Efficacy… · First Affiliated Hospital of Chongqing Medical University · Phase 2
2026-08-21
Primary endpoint(s) modified
NCT05142683 Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled… · Centre for Addiction and Mental Health

Active trials by phase

Early Phase 1
6
Phase 1
18
Phase 1/2
13
Phase 2
67
Phase 2/3
5
Phase 3
46
Phase 4
36
Not charted: 399 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 590

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06103760 Positioning of Esketamine Treatment in the Real-world Management of Depression Royal North Shore Hospital Recruiting 2026-08-12
NCT07105111 A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive… Neurocrine Biosciences Recruiting 2026-06-16
NCT05017311 Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) Nova Scotia Health Authority Recruiting 2026-06-11
NCT05004987 Aβ Dynamics in LLMD NYU Langone Health Recruiting 2026-05-06
NCT05892744 Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression University of Texas at Austin Recruiting 2026-05-01
NCT07478796 TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children Poznan University of Medical Sciences Recruiting 2026-03-18
NCT07076342 The Role of mGluR5 in CBT-I Stony Brook University Recruiting 2026-02-17
NCT07136714 Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder… Nordsjaellands Hospital Recruiting 2026-02-06
NCT07026461 Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided… Region Örebro County Recruiting 2025-12-16
NCT05450432 Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk… Massachusetts General Hospital Recruiting 2025-12-12
NCT06610305 Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual… University of North Carolina, Chapel Hill Recruiting 2025-10-29
NCT07095205 PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine. Stony Brook University Recruiting 2025-07-31
NCT06213324 Neural Circuit Effects of Ketamine in Depression Icahn School of Medicine at Mount Sinai Recruiting 2025-07-03
NCT02752542 Personalized Indications for CBT and Antidepressants in Treating Depression Nova Scotia Health Authority Recruiting 2025-05-14
NCT06223880 A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the… Axsome Therapeutics, Inc. Recruiting 2025-01-23
NCT06675851 Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and… Medical University of Vienna Recruiting 2024-11-05
NCT06417437 Non-invasive BCI and Application Verification for Depressed People Shanghai Mental Health Center Recruiting 2024-05-16
NCT07544966 Teen Vulnerability to Irritability: Brain and Estrogen Changes University of North Carolina, Chapel Hill Not Yet Recruiting 2026-08-24
NCT07139106 Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal… New York State Psychiatric Institute Not Yet Recruiting 2026-08-03
NCT07680140 Biomarker-Guided Antidepressant Selection Weill Medical College of Cornell University Not Yet Recruiting 2026-07-02
NCT05273996 Predictors of Cognitive Outcomes in Geriatric Depression David Steffens Active, Not Recruiting 2026-05-22
NCT07555743 Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and… Institut d'Investigació Biomèdica de Bellvitge Not Yet Recruiting 2026-04-29
NCT07085143 Clinical Study of Compound Ciwujia Granules in the Treatment of Depression Shanghai Mental Health Center Active, Not Recruiting 2026-04-23
NCT06699966 Stony Brook Medicine Anti-Inflammatory Trial Stony Brook University Not Yet Recruiting 2026-04-23
NCT07488910 Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological… Goethe University Not Yet Recruiting 2026-03-23
See all 590 active Major Depressive Disorder trials with filters →

Top sponsors by active trials in this area

Centre for Addiction and Mental Health (13) · Massachusetts General Hospital (11) · Shanghai Mental Health Center (9) · University of California, Los Angeles (8) · First Affiliated Hospital of Chongqing Medical University (7) · National Institute of Mental Health (NIMH) (7) · Stanford University (7) · Neurocrine Biosciences (6) · University of California, San Diego (6) · Yale University (6)

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