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NCT05273996 · ClinicalTrials.gov record · last posted 2026-05-22

Predictors of Cognitive Outcomes in Geriatric Depression

Study acronym: NBOLD
StatusActive, Not Recruiting
PhasePhase 4
Started2021-09-28
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from the ClinicalTrials.gov record
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.

Amendment record 6 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 6 times since 2022-03-01; most recent amendment 2026-05-19. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2024-11-05
Status change Recruiting→Active, Not Recruitingv4
Trial Details
NCT Number NCT05273996
Lead Sponsor David Steffens
Collaborators: National Institute of Mental Health (NIMH)
Conditions Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
Enrollment 75 participants
Start Date 2021-09-28
Primary Completion 2027-04-30 (estimated)
Study Completion 2027-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-22