EXercise-induced PhysioLogical Adaptations In Neurological Disorders

Study acronym: EXPLAIN
StatusRecruiting
PhaseNot applicable
Started

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Record History

  1. Study First Submitted
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases? Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test
Trial Details
NCT Number NCT07883720
Lead Sponsor Brigham and Women's Hospital
Conditions
(from sponsor)		 Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia, Parkinson Disease, Concussion, Brain, Brain Tumor, Healthy
Related terms Brain Concussion, Brain Neoplasms, Cognitive Dysfunction, Conversion Disorder, Dementia, Epilepsy, Motor Activity, Parkinson Disease
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov