Disease landscape

Epilepsy clinical trials

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571 active trials 348 recruiting 54 Phase 3 296 sponsors 53 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days showing 40 of 53 changes on 20 trials

2026-09-09
Trial terminated
Trial terminated: PI has passed away
Sponsor changed: Sanjeet S. Grewal → Mayo Clinic
Final enrollment: 1 participants (planned 5)
Primary completion confirmed: September 2026 (last estimated March 2026)
NCT06280092 Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain… · Mayo Clinic · Early Phase 1
2026-09-16
Primary completion pushed: 2026-12-31 → 2027-06-30
Completion pushed: 2027-05-31 → 2027-10-31
NCT06388707 A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound… · NaviFUS Corporation · Phase 1/2
2026-09-16
Primary completion pushed: 2026-05-31 → 2026-11-30
NCT05339126 RNS System LGS Feasibility Study · NeuroPace · Phase 2
2026-09-11
Primary completion pushed: 2026-07-01 → 2027-06-01
Completion pushed: 2026-07-01 → 2027-06-01
NCT05947656 Evaluation of the NaviFUS System in Drug Resistant Epilepsy · Genovate-NaviFUS (Australia) Pty Ltd.
2026-09-15
Primary completion pushed: 2026-09-23 → 2028-09-23
Completion pushed: 2026-09-23 → 2028-09-23
NCT05101161 Neurofeedback Using Implanted Deep Brain Stimulation Electrodes · ETH Zurich
2026-08-29
Primary completion pushed: 2029-07-01 → 2029-11-01
Completion pushed: 2030-07-01 → 2030-11-01
NCT07301346 EASEE® System Pivotal Study for the United States of America · Precisis US, Inc.
2026-09-12
Primary completion pushed: 2030-12 → 2031-12
Completion pushed: 2030-12 → 2031-12
NCT02813980 Neural Circulatory Control and SUDEP Risk. · Mayo Clinic
2026-09-09
Primary completion pushed: 2026-07-31 → 2027-07-31
NCT04170491 EEG Monitoring for Refractory Status Epilepticus · Barts & The London NHS Trust
2026-09-04
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT06143293 RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS · University of Minnesota
2026-08-29
Primary completion pushed: 2028-04 → 2028-09
Completion pushed: 2028-04 → 2028-09
NCT07520955 Lily's Grace Temporal Interference · University of Wisconsin, Madison
2026-08-27
Primary completion pushed: 2026-08 → 2027-08
Completion pushed: 2026-08 → 2027-08
NCT00575081 Physiological Brain Atlas Development · Vanderbilt University Medical Center
2026-08-27
Primary completion pushed: 2026-02-19 → 2027-03
Enrollment closed, study ongoing
Completion pushed: 2026-08 → 2027-03
NCT05559749 Collaborative Care for Anxiety and Depression in Epilepsy · Wake Forest University Health Sciences
2026-09-11
Primary endpoint(s) modified
NCT07735715 HOBSCOTCH-YOUTH and Young Adults · Dartmouth-Hitchcock Medical Center
2026-09-16
Trial status changed: Enrolling by Invitation → Completed
Final enrollment: 70 participants (planned 100)
NCT05152992 Spatiotemporal Dynamics of the Human Emotion Network · University of California, San Francisco
2026-09-12
Trial completed
Final enrollment: 12 participants (planned 8)
Primary completion confirmed: June 2026 (last estimated March 2026)
NCT05019885 The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant… · Madeline Fields · Phase 2
2026-09-02
Trial completed
Final enrollment: 5 participants (planned 10)
Study completion confirmed: August 2026 (last estimated October 2026)
NCT06340802 A First in hUman Study for Resistant Epilepsy With the Vagus Nerve stimulatiOn Device by… · Synergia Medical
2026-08-22
Enrolling by invitation only
NCT07775976 Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using… · Peerbridge Health, Inc
2026-08-28
Primary completion pushed: 2026-08-31 → 2026-09-30
Completion pushed: 2026-08-31 → 2026-09-30
NCT05077904 A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12… · UCB Biopharma SRL · Phase 3
2026-09-16
Trial sites expanded: 55 → 58 locations
NCT05066217 An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome · Epygenix · Phase 3
2026-09-10
Primary completion pushed: 2026-10-01 → 2026-12-01
NCT06634901 Health Literacy Project · Duke University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-04 NCT07803692 High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for… Oregon Health and Science University new
2026-08-28 NCT07793396 Prospective Study of Eslicarbazepine in Adults With Focal-Onset Seizures King Edward Medical University new
2026-08-27 NCT07790224 Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing… Beijing Sanbo Brain Hospital new
2026-08-20 NCT07775976 Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using… Peerbridge Health, Inc new
2026-08-07 NCT07753681 Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health… Centre for Infectious Disease Research in Zambia new
2026-08-04 NCT07745608 Occupational Therapy Approach in ARX-Related Epilepsy Uskudar University new
2026-07-23 NCT07723287 Risk Factors for Drug-Resistant Epilepsy in Children Pham Ngoc Thach University of Medicine new
2026-07-21 NCT07716930 Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy Kemal Tutkavul new
2026-07-20 NCT07714226 A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body… Wroclaw Medical University new
2026-07-20 NCT07713706 Neural Mechanisms for Stopping Ongoing Speech Production (Study 2) Lingyun Zhao new

Active trials by phase

Early Phase 1
13
Phase 1
14
Phase 1/2
14
Phase 2
30
Phase 2/3
8
Phase 3
46
Phase 4
19
Not charted: 427 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 571

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07750496 Outcomes After Planned Discontinuation of AntiSeizure Medication University of Michigan Recruiting 2026-08-06
NCT07112365 The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project The University of Texas Health Science Center, Houston Recruiting 2026-07-15
NCT06598449 Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24… University of Colorado, Denver Recruiting 2026-05-15
NCT04419272 Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits VA Office of Research and Development Recruiting 2026-04-20
NCT07193277 Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy First Affiliated Hospital of Wenzhou Medical University Recruiting 2025-09-25
NCT07072624 Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) All India Institute of Medical Sciences, Jodhpur Recruiting 2025-08-06
NCT07046676 Pharmacogenetics-Based Study on Individualized Use of Sodium Valproate The First Affiliated Hospital of University of South China Recruiting 2025-07-10
NCT06967012 A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in… Affiliated Hospital of Nantong University Recruiting 2025-05-13
NCT04144439 Effect of GABA on ADHD and Seizures in Children With Epilepsy. Sherief Abd-Elsalam Recruiting 2019-10-30
NCT06534502 Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month… Azurity Pharmaceuticals Not Yet Recruiting 2026-09-15
NCT06924827 A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to… Elizabeth Donner Not Yet Recruiting 2026-09-11
NCT07728097 A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment… Jazz Pharmaceuticals Not Yet Recruiting 2026-08-31
NCT06453213 Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or… SK Life Science, Inc. Active, Not Recruiting 2026-08-27
NCT05044819 Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex… Jazz Pharmaceuticals Active, Not Recruiting 2026-08-26
NCT06346262 Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management… University Hospitals Cleveland Medical Center Active, Not Recruiting 2026-07-06
NCT07284498 Treatment of Seizures in Neonate With HIE Mansoura University Not Yet Recruiting 2025-12-16
NCT07177235 Ketamine for the Treatment of Refractory Status Epilepticus Thomas Jefferson University Not Yet Recruiting 2025-09-16
NCT02670161 Quality Improvement and Practice Based Research in Neurology Using the EMR Endeavor Health Enrolling by Invitation 2025-08-24
NCT06838559 Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no… University of Colombo Active, Not Recruiting 2025-02-24
Phase 3
NCT04462770 A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome Epygenix Recruiting 2026-09-15
NCT05066217 An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome Epygenix Recruiting 2026-09-15
NCT05077904 A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12… UCB Biopharma SRL Recruiting 2026-09-11
NCT07594119 Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal… Rapport Therapeutics Inc. Recruiting 2026-09-02
NCT07563881 Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal… Rapport Therapeutics Inc. Recruiting 2026-09-01
NCT06872125 A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in… Stoke Therapeutics, Inc Recruiting 2026-08-24
See all 571 active Epilepsy trials with filters →

Top sponsors by active trials in this area

Xuanwu Hospital, Beijing (18) · Hospices Civils de Lyon (14) · Assistance Publique - Hôpitaux de Paris (12) · Assiut University (10) · Fondation Ophtalmologique Adolphe de Rothschild (10) · Mayo Clinic (10) · Duke University (9) · University of California, San Francisco (9) · Assistance Publique Hopitaux De Marseille (7) · Jazz Pharmaceuticals (7)

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