Epilepsy clinical trials
Data updated daily from ClinicalTrials.gov, last refresh 2026-11-05
What changed in the last 30 days
47 trials changed in the last 30 days: 2 stopped, 26 with notable changes, 19 with minor changes only.
- Notable: UX-GIP001 · Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy Recruitment opened
- Minor: OPERA · Follow-Up of a Cohort of Participants Prescribed Epidyolex in France in a Real-life Setting Trial completed
- Notable: HOBSCOTCH-YOUTH and Young Adults Primary completion pushed from Sep 1, 2028 to May 1, 2029
- Minor: X-ACKT · XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures Trial sites expanded: 138 → 141 locations
- Minor: BLUELIGHTVNS · Blue Light on Vagus Nerve Stimulation · Refractory Epilepsy Study completion pushed from Apr 2026 to Dec 2026
- Notable: CoSMos · Combined CM and STN Stimulation for Motor Epilepsy Recruitment opened
- Minor: SLEEP-TIES · Lily's Grace Temporal Interference Start date pushed from Oct 2026 to Nov 2026
- Notable: ARGUS · EPX-100 (Clemizole Hydrochloride) · Dravet Syndrome Primary endpoint(s) modified
- Minor: TSC-STEPS · Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study Enrollment closed, study ongoing
- Notable: HIFU for MRGE · High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus · Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years Primary endpoint(s) modified
- Notable: Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG) Primary and study completion pushed from Aug 3, 2026 to Dec 31, 2027
- Minor: SPN-817 Open-Label Extension Study · Focal Onset Seizures Trial status changed: Recruiting → Enrolling by Invitation
- Minor: LP352 in Children and · Dravet Syndrome (DS) Enrollment increased: 96 → 108 participants
- Minor: BTSEE · Biomarker Targeted Stimulation for Epileptiform Events Study completion pushed from Feb 14, 2030 to Nov 1, 2030
- Minor: Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures Primary and study completion pushed from Oct 31, 2026 to Mar 29, 2027
- Minor: FOCUS 1 · RAP-219 · Focal Seizures FOCUS-1 Trial sites expanded: 15 → 18 locations
- Notable: ENDEAVOR · ETX101 in Infants and · SCN1A-Positive Dravet Syndrome Enrollment increased: 47 → 113 participants
- Notable: RaRE-TS · Rapamycin in Drug Resistant Epilepsy Associated With Tuberous Sclerosis Complex Primary and study completion pushed from Jun 2027 to Sep 2029
- Minor: DETECT LTFU · Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up Trial sites expanded: 18 → 21 locations
- Notable: Oxygen Toxicity: Mechanisms in Humans Recruitment resumed after suspension
- Stopped: terminated, suspended or withdrawn
- Notable: the plan changed
- Minor: routine updates
New sponsor entrants, last 90 days sponsors with their first trial in this area
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-11-03 | NCT07911774 Edge AI Neurostimulation Controllers Versus Continuous Therapy for Drug-Resistant Focal… | Lahore Medical and Dental College new | |
| 2026-10-29 | NCT07904039 Characterisation of Laryngeal Evoked Potentials Induced by Vagus Nerve Stimulation in… | Université Catholique de Louvain new | |
| 2026-10-08 | NCT07865546 Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI | Imago 7 Fondazione di Ricerca onlus new | |
| 2026-10-02 | NCT07854093 Impact of Epilepsy on Motor Function, Fatigue, and Quality of Life | Borna Farhoomand new | |
| 2026-09-23 | NCT07835594 Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People… | Acibadem University new | |
| 2026-09-18 | NCT07828496 Cognitive Rehabilitation Using Neurofeedback With Brain-computer Interface | KK Women's and Children's Hospital new | |
| 2026-09-16 | NCT07821697 Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG… | Adraxe Corp. new | Early Phase 1 |
| 2026-08-28 | NCT07793396 Prospective Study of Eslicarbazepine in Adults With Focal-Onset Seizures | King Edward Medical University new | |
| 2026-08-27 | NCT07790224 Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing… | Beijing Sanbo Brain Hospital new | |
| 2026-08-20 | NCT07775976 Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using… | Peerbridge Health, Inc new |
Active trials by phase
| Early Phase 1 | 15 | |
| Phase 1 | 13 | |
| Phase 1/2 | 19 | |
| Phase 2 | 32 | |
| Phase 2/3 | 9 | |
| Phase 3 | 44 | |
| Phase 4 | 21 |
Not charted: 469 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).
Top sponsors by active trials in this area
Xuanwu Hospital, Beijing (18) · Hospices Civils de Lyon (14) · Assiut University (13) · Assistance Publique - Hôpitaux de Paris (12) · Fondation Ophtalmologique Adolphe de Rothschild (10) · Mayo Clinic (10) · University of California, San Francisco (10) · Duke University (9) · Assistance Publique Hopitaux De Marseille (8) · National Institute of Neurological Disorders and Stroke (NINDS) (7)
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