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NCT07790224

Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing SEEG Monitoring

StatusNot Yet Recruiting
PhaseNot applicable
Primary completion (estimated)
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Record History

All 1 version: 1 with changes below.

  1. Study First Submitted

Endpoints

Primary

Change From Pre-stimulation Baseline in SEEG Power Spectral Density
Timeframe: On each stimulation day (Day 1 and, if applicable, Day 2), assessed immediately before each TI stimulation condition, during the 90-second stimulation period, and immediately after completion of the stimulation condition.

Secondary (1)

Change in Cortical-Cortical Evoked Potential (CCEP) Amplitude Following TI Stimulation

Arms and interventions

Multi-Parameter Temporal Interference StimulationExperimental

Participants will receive multi-parameter temporal interference (TI) stimulation targeting one or two individualized deep brain regions selected according to SEEG electrode coverage and neuroimaging data. For each target, multiple stimulation frequencies will be administered in a randomized within-participant sequence, with SEEG activity recorded before, during, and after each stimulation condition. Repeated stimulation sequences and cortical-cortical evoked potential measurements will be performed to characterize the reproducibility and neurophysiological effects of TI stimulation.

Devices: Temporal Interference Stimulation

Sites

1 site in 1 country

  • Beijing Sanbo Brain HospitalBeijing, Beijing Municipality, China