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Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

StatusActive, Not Recruiting
PhasePhase 2
Started2015-08-17
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Dec 31, 2026 → Dec 31, 2027
See other at-risk trials from National Cancer Institute (NCI)

Amendment history

The 50 most recent of 1414 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

2026-09-30
Primary completion pushed: 2026-12-31 → 2027-12-31
Completion pushed: 2026-12-31 → 2027-12-31
2026-08-27
Study Status, Contacts/Locations v1413
Study sites1410 entries, revised
Kaiser Permanente-Rio San Diego Mission
2026-08-01
Study Status, Contacts/Locations v1412
Study sites1411→1410
2026-07-30
Study Status, Contacts/Locations v1411
Study sites1411 entries, revised
UniversityUPMC of PittsburghHillman Cancer Institute (UPCI)Center
2026-07-29
Study Status, Contacts/Locations v1410
Study sites1411 entries, revised
SaintCooperman Barnabas Medical Center
Show 46 earlier versions
2026-07-09
2 amendments v1408-v1409
2 re-verifications since 2026-07-07, no change to tracked fields
2026-07-01
Study Status, Contacts/Locations v1407
Study sites1411 entries, revised
FlagetCommonSpirit Memorial Hospital Saint Joseph Hospital East- Bardstown CommonSpirit Saint Joseph Medical Center - East Lexington CommonSpirit Saint Joseph Hospital London Lahey HospitalClinic UT and Medical Center MD Anderson in- The Woodlands UT MD Anderson - West Houston LangladeAspirus HospitalCancer andCare-Antigo-Volm Cancer Center Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield Ascension Calumet Hospital-Chilton Ascension Saint Francis Hospital-Milwaukee Aspirus Cancer Care-Rhinelander-James Beck Cancer Center Ascension Medical Group Southeast Wisconsin Hospital-May [...] [...]
2026-06-30
Study Status, Contacts/Locations v1406
Study sites1411 entries, revised
Ascension Northeast Wisconsin-Saint Elizabeth HospitalCancer Center-Appleton Ascension Saint Francis - Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson Ascension Columbia Saint Mary's Hospital-Ozaukee OzaukeeCampus-Mequon Ascension Columbia Saint Mary's Hospital-Milwaukee - MilwaukeeCampus Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh Ascension All Saints Hospital-Spring Street-Racine Aspirus Regional Cancer CenterCare-Wausau
2026-06-25
Study Status, Contacts/Locations v1405
Study sites1411 entries, revised
Ascension Southeast Wisconsin Hospital-Saint Joseph Campus-Milwaukee
2026-06-24
Study Status, Contacts/Locations v1404
Study sites1411 entries, revised
UT MD Anderson in- Sugar Land
2026-06-16
Study Status, Contacts/Locations v1403
Study sites1411 entries, revised
Lahey MedicalClinic Center-Peabody MUT DMD Anderson Cancer Center UT MD Anderson - League City
2026-06-12
Study Status, Contacts/Locations v1402
Study sites1412→1411
2026-06-02
Study Status, Arms and Interventions v1401
Re-verified, no change to tracked fields
2026-05-28
Study Status, Contacts/Locations v1400
Study sites1412 entries, revised
CommonSpirit Saint Anthony Hospital Saint Michael Cancer Center Saint Joseph Medical Center Hematology and Oncology - Silverdale
2026-05-22
Study Status, Contacts/Locations v1399
Study sites1413→1412
2026-05-12
Study Status, Arms and Interventions v1398
Re-verified, no change to tracked fields
2026-05-01
Study Status, Contacts/Locations v1397
Study sites1413 entries, revised
Cedars-Sinai Medical Center
2026-04-30
Study Status, Contacts/Locations v1396
Study sites1414→1413
2026-04-09
8 amendments v1388-v1395
8 re-verifications since 2026-03-31, no change to tracked fields
2026-03-28
Study Status, Contacts/Locations v1387
Study sites1414 entries, revised
Lowcountry Hematology Oncology PAAssociates - West Ashley Lowcountry Hematology Oncology PAAssociates - Mount Pleasant
2026-03-27
10 amendments v1377-v1386
10 re-verifications since 2026-03-14, no change to tracked fields
2026-03-13
Study Status, Contacts/Locations v1376
Study sites1414 entries, revised
Dartmouth Cancer Center - Manchester/ DCC Manchester
2026-03-12
12 amendments v1364-v1375
12 re-verifications since 2026-02-25, no change to tracked fields
National Cancer Institute (NCI)
960 trials monitored
See 69 trials at risk
Breast Cancer
5,180 trials monitored
See 256 trials at risk
Lung Cancer
4,033 trials monitored
See 210 trials at risk
Colorectal Cancer
2,904 trials monitored
See 127 trials at risk
and 15 more diseases
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and does not respond to treatment (refractory). Patients must have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
Trial Details
NCT Number NCT02465060
Lead Sponsor National Cancer Institute (NCI)
Conditions Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma, Cervical Carcinoma, Colon Carcinoma, Colorectal Carcinoma, Endometrial Carcinoma +44 more
Enrollment 6,452 participants
Start Date 2015-08-17
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-10-01