| Detected | Trial | Change |
|---|---|---|
| 2026-06-05 | NCT04895709 A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… |
Primary endpoint(s) modified |
| 2026-06-05 | NCT04895709 A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… |
Enrollment increased: 949 -> 1109 participants |
| 2026-06-05 | NCT04895709 A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… |
Trial arms changed: 7 -> 9 |
| 2026-06-05 | NCT04895709 A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… |
date change Primary completion pushed: 2028-07-07 -> 2031-08-31 |
| 2026-06-05 | NCT04895709 A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… |
date change Completion pushed: 2028-07-07 -> 2031-08-31 |
| 2026-06-03 | NCT07291076 A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With… |
Enrollment increased: 129 -> 198 participants |
| 2026-06-03 | NCT07291076 A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With… |
Trial arms changed: 6 -> 7 |
| 2026-06-03 | NCT07291076 A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With… |
Trial sites expanded: 50 -> 59 locations |
| 2026-06-02 | NCT06712355 Safety and Efficacy of BNT327, an Investigational Therapy in Combination With… |
Trial sites expanded: 138 -> 202 locations |
| 2026-05-30 | NCT07492680 A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants… |
Trial sites expanded: 55 -> 58 locations |
| 2026-05-29 | NCT07221357 A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy… |
Trial sites expanded: 279 -> 286 locations |
| 2026-05-27 | NCT07293351 A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in… |
Trial arms changed: 10 -> 9 |
| 2026-05-23 | NCT06953089 DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors |
Trial arms changed: 8 -> 13 |
| 2026-05-23 | NCT07070232 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… |
Trial sites expanded: 53 -> 64 locations |
| 2026-05-23 | NCT07173751 ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative… |
Trial sites expanded: 83 -> 104 locations |
| 2026-05-23 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
Trial sites expanded: 206 -> 225 locations |
| 2026-05-20 | NCT06892548 A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination… |
Trial sites expanded: 58 -> 76 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT07173751 | ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative… | Breast Neoplasms | Recruiting |
| NCT06712355 | Safety and Efficacy of BNT327, an Investigational Therapy in Combination With… | Extensive-stage Small-cell Lung Cancer | Recruiting |
| NCT07361497 | A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation… | Non-small Cell Lung Cancer (NSCLC) | Recruiting |
| NCT07361510 | A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With… | Non-Small Cell Lung Cancer (NSCLC) | Recruiting |
| NCT06616532 | PM8002 in Combination With Paclitaxel Compared With Chemotherapy as Second-line Treatment… | SCLC | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT06712316 | Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… | Non-small Cell Lung Cancer | Recruiting |
| NCT07221357 | A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy… | Untreated, Unresectable, or Metastatic Colorectal Cancer | Recruiting |
| NCT07221149 | A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy… | Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma | Recruiting |
| Phase 2 | |||
| NCT06841055 | Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for… | Non-small Cell Lung Cancer | Recruiting |
| NCT07255404 | A Clinical Trial Testing the Safety of BNT327 (an Investigational Drug) and How Well it… | Pancreatic Ductal Adenocarcinoma (PDAC) | Recruiting |
| NCT07297212 | A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and… | Recurrent Glioblastoma | Recruiting |
| NCT06953089 | DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors | Solid Tumors | Recruiting |
| NCT07492680 | A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants… | Solid Tumors | Not Yet Recruiting |
| Phase 1/2 | |||
| NCT07147348 | A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as… | Advanced Solid Tumor | Recruiting |
| NCT07079631 | A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in… | Metastatic Colorectal Cancer | Recruiting |
| NCT07111520 | A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… | Non-small Cell Lung Cancer | Recruiting |
| NCT06618287 | A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of… | Lung Cancer | Recruiting |
| NCT06827236 | A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323… | Locally Advanced Breast Cancer | Recruiting |
| NCT06892548 | A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination… | Advanced Lung Cancer | Recruiting |
| NCT07070232 | A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… | Advanced Solid Tumor | Recruiting |
| NCT07293351 | A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in… | Advanced Renal Cell Carcinoma (RCC) | Recruiting |
| NCT07291076 | A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With… | Hepatocellular Carcinoma (HCC) | Recruiting |
| NCT04895709 | A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With… | Cervical Cancer | Recruiting |
| NCT05438329 | First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors | Advanced Solid Tumor | Active, Not Recruiting |
| NCT07579221 | Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell… | Non-Small Cell Lung Cancer | Not Yet Recruiting |