Drug Pipeline

Polatuzumab Vedotin Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
29
Active Studies
16
Recruiting
2
Phase 3
10
Top Sponsors
3
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-02 NCT04739813
Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With…
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-02 NCT04739813
Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With…
Enrollment reduced: 55 -> 34 participants
2026-06-02 NCT04739813
Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With…
date change Primary completion moved earlier: 2026-06-18 -> 2026-05-07
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-10 NCT07638722 Testing Mosunetuzumab Alone, With Zanubrutinib, or With Polatuzumab Vedotin for Treating… Phase 2 Not Yet Recruiting
2026-06-10 NCT07638787 Pola-R-CHP Plus Sonrotoclax in Untreated BCL2-High/Double-Hit LBCL Phase 1/2 Not Yet Recruiting
2026-05-19 NCT07594899 AI-Driven Treatment Strategy vs Pola-R-CHP in Untreated LBCL Phase 2 Not Yet Recruiting
Active Studies by Phase
Phase 3
2
Phase 2
14
Phase 1/2
5
Phase 1
7
Not specified
1
Active Trials — top 25 of 29
NCT IDTitleConditionStatus
Phase 3
NCT06047080 An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab… Large B-Cell Lymphoma Active, Not Recruiting
NCT05171647 A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab… Non-Hodgkin Lymphoma Active, Not Recruiting
Phase 2
NCT05260957 CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed… Refractory Non-Hodgkin Lymphoma Recruiting
NCT06043674 Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or… Chronic Lymphocytic Leukemia Recruiting
NCT05633615 Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory… Diffuse Large B-Cell Lymphoma Recruiting
NCT07397832 CRP Regimen in Treating Elderly Patients With Previously Untreated Double-Positive DLBCL Diffuse Large B-Cell Lymphoma (DLBCL) Recruiting
NCT05800366 A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse… Lymphoma Recruiting
NCT05615636 A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients… Hodgkin Lymphoma Recruiting
NCT05283720 A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC)… Non-Hodgkin Lymphoma Recruiting
NCT06765317 A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma Diffuse Large B Cell Lymphoma (DLBCL) Recruiting
NCT06890884 A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide… Lymphoma, Large B-Cell, Diffuse Recruiting
NCT07502872 TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse… Diffuse Large B Cell Lymphoma Not Yet Recruiting
NCT05798156 Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With… Lymphoma, Large B-Cell, Diffuse Active, Not Recruiting
NCT06594939 Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly… Diffuse Large B Cell Lymphoma (DLBCL) Not Yet Recruiting
NCT07594899 AI-Driven Treatment Strategy vs Pola-R-CHP in Untreated LBCL Large B-Cell Lymphoma (LBCL) Not Yet Recruiting
NCT07638722 Testing Mosunetuzumab Alone, With Zanubrutinib, or With Polatuzumab Vedotin for Treating… Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Not Yet Recruiting
Phase 1/2
NCT04491370 Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell… B-cell Lymphoma Recruiting
NCT06040320 Polatuzumab Vedotin (Pola) Plus Rituximab (R) in Patients With Post-transplant… Post-transplant Lymphoproliferative Disorder Recruiting
NCT07415980 Phase Ib/II Study of Polatuzumab Vedotin in Combination With Rituximab and Chidamide in… Double Expressor DLBCL Not Yet Recruiting
NCT03533283 An Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in… Non-Hodgkins Lymphoma Active, Not Recruiting
NCT07638787 Pola-R-CHP Plus Sonrotoclax in Untreated BCL2-High/Double-Hit LBCL Large B-cell Lymphoma Not Yet Recruiting
Phase 1
NCT04231877 Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the… Aggressive Non-Hodgkin Lymphoma Recruiting
NCT06015880 Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and… Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Recruiting
NCT06730542 Zanubrutinib in Combination With Pola-R-CHP and High-dose Methotrexate in Patients With… CNS Lymphoma Recruiting
NCT04884035 Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to… Lymphoma, B-Cell Recruiting
Sponsors Running Polatuzumab Vedotin Trials
Disease Areas
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