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TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma

Study acronym: TPG
StatusNot Yet Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 31 days later Dec 1, 2029 → Jan 1, 2030
See other at-risk trials from Brown University

Record History

  1. Notable Start date: May 1, 2026 to Nov 1, 2026
    • Primary and study completion pushed from Dec 1, 2029 to Jan 1, 2030
    • Secondary endpoints: details revised at 3 of 8 entries
    • Site contact updated
    v2
  2. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
703 trials monitored
See 44 trials at risk
This is a single-center, phase 2, open-label clinical trial of a novel combination of polatuzumab vedotin, glofitamab, and tafasitamab (TPG) as first-line treatment of patients with diffuse large B cell lymphoma (DLBCL) or high-grade B cell lymphoma (HGBL).
Trial Details
NCT Number NCT07502872
Lead Sponsor Brown University
Collaborators: Incyte Corporation, Genentech, Inc., Natera, Inc.
Conditions
(from sponsor)
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Lymphoma, Lymphoma, B-Cell
Related terms Lymphoma, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov