Drug Pipeline

Liposomal Bupivacaine Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
20
Active Studies
9
Recruiting
5
Phase 3
10
Top Sponsors
5
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-05-29 NCT07587203
Effect of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Superior Trunk Block of…
Primary endpoint(s) modified
2026-05-15 NCT07366905
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
overall status: "Not Yet Recruiting" → "Completed"
2026-05-15 NCT07366905
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
Enrollment increased: 60 -> 79 participants
2026-05-15 NCT07366905
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
date change Primary completion pushed: 2026-03 -> 2026-03-31
2026-05-15 NCT07366905
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
date change Completion pushed: 2026-03 -> 2026-04-01
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-05-26 NCT07606911 Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in… Phase 4 Not Yet Recruiting
2026-05-14 NCT07587203 Effect of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Superior Trunk Block of… Enrolling by Invitation
Active Studies by Phase
Phase 4
6
Phase 3
4
Phase 2/3
1
Phase 2
5
Phase 1
1
Not specified
3
Active Trials
NCT IDTitleConditionStatus
Phase 4
NCT06213454 Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in… Analgesia Recruiting
NCT07512635 Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in… Pulmonary Nodule Not Yet Recruiting
NCT07097493 Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in… Knee Arthroplasty, Total Not Yet Recruiting
NCT07570940 A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial… Coronary Artery Disease Not Yet Recruiting
NCT07584915 Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA)… Total Knee Arthroplasty Enrolling by Invitation
NCT07606911 Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in… Acute Pain Not Yet Recruiting
Phase 3
NCT07092566 R.E.C.K vs Exparel in Robotic Nephrectomy Renal Carcinoma Recruiting
NCT07212114 Efficacy of EXPAREL vs. Bupivacaine Total Ankle Arthroplasty Recruiting
NCT03214510 Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in… Liver and Intrahepatic Bile Duct Disorder Active, Not Recruiting
NCT05964868 Efficacy of Liposomal Bupivacaine Post Septorhinoplasty Rhinoplasty Enrolling by Invitation
Phase 2/3
NCT06077422 Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain Pain, Postoperative Enrolling by Invitation
Phase 2
NCT06411795 Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for… Duodenal Neoplasm Recruiting
NCT06559215 Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population Medial Patellofemoral Ligament (MPFL) Reconstruction Recruiting
NCT04930887 Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the… Craniofacial Pain Recruiting
NCT05044468 EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural… Malignant Pleural Neoplasm Active, Not Recruiting
NCT04189783 Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After… Retroperitoneal Sarcoma Active, Not Recruiting
Phase 1
NCT06271265 Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia… Postoperative Pain Recruiting
Not specified
NCT07271979 Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in… Liposomal Bupivacaine Recruiting
NCT07509866 Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine… Total Knee Anthroplasty Recruiting
NCT07587203 Effect of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Superior Trunk Block of… Proximal Humerus Surgery Enrolling by Invitation
Sponsors Running Liposomal Bupivacaine Trials
Disease Areas
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