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Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty

StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 5 months later Dec 31, 2026 → Jun 2027
See other at-risk trials from Wake Forest University Health Sciences

Record History

  1. Start date: Aug 2026 to Feb 2027
    • Primary and study completion pushed from Dec 31, 2026 to Jun 2027
    v7
  2. Start date: Apr 2026 to Aug 2026v6
  3. Start date: Feb 2026 to Apr 2026v5
  4. Start date: Jan 2026 to Feb 2026v4
  5. Start date: Dec 1, 2025 to Jan 2026v3
  6. Re-verified, no change to tracked fieldsv2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery. The drugs being used are liposomal bupivacaine compared to a combination of bupivacaine, clonidine, epinephrine, buprenorphine, and dexamethasone. Pain scores will be collected at different intervals during study participation.
Trial Details
NCT Number NCT07097493
Lead Sponsor Wake Forest University Health Sciences
Conditions
(from sponsor)		 Knee Arthroplasty, Total
Related terms Agnosia, Pain
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov