Drug Pipeline

Aldesleukin Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
43
Active Studies
28
Recruiting
10
Top Sponsors
4
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-09 NCT02621021
A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor…
Enrollment reduced: 170 -> 53 participants
2026-05-20 NCT05989828
A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1…
date change Primary completion pushed: 2026-12-17 -> 2027-12-31
2026-05-20 NCT05989828
A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1…
date change Completion pushed: 2027-12-17 -> 2028-12-31
2026-05-20 NCT07591649
Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT
Recruitment opened
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-05-28 NCT07610538 Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on… Recruiting
2026-05-18 NCT07591649 Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT Phase 1/2 Recruiting
Active Studies by Phase
Phase 2
11
Phase 1/2
13
Phase 1
16
Early Phase 1
2
Not specified
1
Active Trials — top 25 of 43
NCT IDTitleConditionStatus
Phase 2
NCT07288073 TIL Therapy in cSCC and MCC Cutaneous Squamous Cell Carcinoma Recruiting
NCT05686226 E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers Cervical Cancer Recruiting
NCT04562129 IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients Melanoma Stage III Recruiting
NCT03412877 Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors… Endocrine Tumors Recruiting
NCT05155033 Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal… Metastatic Melanoma Recruiting
NCT02133196 T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer Advanced Non-Small Cell Lung Cancer Recruiting
NCT02621021 A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor… Melanoma Recruiting
NCT01174121 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer Metastatic Colorectal Cancer Recruiting
NCT01366092 Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease Chronic Graft-versus-host Disease Active, Not Recruiting
NCT00338377 Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization… Melanoma Active, Not Recruiting
NCT03449108 LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer… Bone Sarcoma Active, Not Recruiting
Phase 1/2
NCT04263831 Low Dose IL-2 for the Treatment of Crohn's Disease Crohn Disease Recruiting
NCT05639972 E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced… HPV-Associated Cervical Carcinoma Recruiting
NCT06961357 Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma Melanoma Recruiting
NCT02830724 Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric… Pancreatic Cancer Recruiting
NCT06158828 Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted… AML, Childhood Recruiting
NCT05267626 Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in… Advanced Solid Tumor Recruiting
NCT07591649 Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT Relapsed Adult AML Recruiting
NCT06598371 A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to… Select Advanced Solid Tumors Recruiting
NCT03190941 Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor… Pancreatic Cancer Recruiting
NCT03474497 UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint… Non Small Cell Lung Cancer Active, Not Recruiting
NCT06237881 A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to… Advanced Solid Tumor Active, Not Recruiting
NCT07389239 A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced… Ovarian Cancer Not Yet Recruiting
NCT01038778 Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney… Clear Cell Renal Cell Carcinoma Active, Not Recruiting
Phase 1
NCT06138587 Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation Acute Myeloid Leukemia Recruiting
Sponsors Running Aldesleukin Trials
Disease Areas
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