Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells

The primary goals of this study are to compare the differences in tissue-resident Treg gene signature for activation, proliferation, and suppressive function using single-cell/-nucleus RNA sequencing in patients treated with ld-IL-2 compared to control grouped by individual tissue beds from in and around the heart. Additionally, tissue-resident Tregs will be compared to peripheral blood Tregs from the same patient to assess the differential effect of ld-IL-2 on the two compartments.

NCT Number	NCT07610538
Lead Sponsor	Cambridge University Hospitals NHS Foundation Trust Collaborators: Royal Papworth Hospital
Conditions	Coronary Artery Disease, Myocardial Infarction (MI), CABG
Enrollment	24 participants
Start Date	2026-03-31
Primary Completion	2028-11-01 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-28