| Detected | Trial | Change |
|---|---|---|
| 2026-06-09 | NCT04613596 Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… |
Trial sites expanded: 767 -> 770 locations |
| 2026-05-21 | NCT04613596 Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… |
Enrollment reduced: 806 -> 626 participants |
| 2026-05-21 | NCT04613596 Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… |
Trial sites expanded: 764 -> 767 locations |
| 2026-05-21 | NCT04613596 Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… |
date change Primary completion pushed: 2028-10-31 -> 2032-06-09 |
| 2026-05-21 | NCT04613596 Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… |
date change Completion pushed: 2029-10-31 -> 2032-06-09 |
| 2026-05-16 | NCT07415031 A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in… |
Recruitment opened |
| 2026-05-16 | NCT07415031 A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in… |
Trial sites expanded: 30 -> 77 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06875310 | A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab… | Carcinoma, Non-Small-Cell Lung | Recruiting |
| NCT06497556 | A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in… | Non-Small Cell Lung Cancer | Active, Not Recruiting |
| NCT04793958 | Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced… | Advanced Colorectal Cancer | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT04613596 | Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… | Advanced Non-Small Cell Lung Cancer | Recruiting |
| Phase 2 | |||
| NCT06248606 | Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain… | Non Small Cell Lung Cancer | Recruiting |
| NCT07288034 | Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and… | Lung Non-Small Cell Carcinoma | Recruiting |
| NCT07415031 | A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in… | Solid Tumors | Recruiting |
| NCT05853575 | Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) | Advanced Cancer | Active, Not Recruiting |
| NCT03994796 | Genetic Testing in Guiding Treatment for Patients With Brain Metastases | CDK Gene Mutation | Active, Not Recruiting |
| NCT07543172 | CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non… | Advanced Lung Non-Small Cell Carcinoma | Not Yet Recruiting |
| NCT05673187 | Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance… | NSCLC Stage IV | Active, Not Recruiting |
| Phase 1/2 | |||
| NCT06412198 | A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic… | Metastatic Colorectal Cancer | Recruiting |
| Phase 1 | |||
| NCT06764771 | A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With… | Advanced Malignant Tumors | Recruiting |
| NCT06026410 | KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors | Solid Tumors With HRAS Alterations | Recruiting |
| NCT07382726 | Phase 1 Study Of Izalontamab Brengitecan + Adagrasib In NSCLC - The IZA-A Trial | Non-small Cell Lung Cancer | Not Yet Recruiting |
| NCT05722327 | Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in… | Colon Cancer | Active, Not Recruiting |
| Early Phase 1 | |||
| NCT07318389 | ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic… | Dynamic Tumor Resistance | Not Yet Recruiting |