| Detected | Trial | Change |
|---|---|---|
| 2026-08-15 | NCT05853575 Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) |
date change Primary completion moved earlier: 2026-11-30 -> 2026-10-30 |
| 2026-08-12 | NCT04685135 Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small… |
Trial sites expanded: 343 -> 380 locations |
| 2026-08-12 | NCT04685135 Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small… |
date change Completion pushed: 2026-07-02 -> 2026-10-30 |
| 2026-08-05 | NCT05853575 Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) |
date change Primary completion pushed: 2026-07-30 -> 2026-11-30 |
| 2026-08-05 | NCT05853575 Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) |
date change Completion pushed: 2026-07-30 -> 2026-11-30 |
| 2026-07-30 | NCT03785249 Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 |
date change Primary completion moved earlier: 2026-12-31 -> 2026-06-23 |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-07-23 | NCT07723118 A Study to Assess the Pharmacokinetics, Safety and Tolerability of Single-dose Adagrasib… | Phase 1 | Not Yet Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06875310 | A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab… | Carcinoma, Non-Small-Cell Lung | Recruiting |
| NCT04793958 | Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced… | Advanced Colorectal Cancer | Active, Not Recruiting |
| NCT04685135 | Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small… | Metastatic Non Small Cell Lung Cancer | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT04613596 | Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase… | Advanced Non-Small Cell Lung Cancer | Recruiting |
| Phase 2 | |||
| NCT07415031 | A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in… | Solid Tumors | Recruiting |
| NCT05609578 | Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C… | Advanced NSCLC | Active, Not Recruiting |
| NCT05853575 | Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) | Advanced Cancer | Active, Not Recruiting |
| Phase 1/2 | |||
| NCT03785249 | Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 | Advanced Cancer | Active, Not Recruiting |
| Phase 1 | |||
| NCT07723118 | A Study to Assess the Pharmacokinetics, Safety and Tolerability of Single-dose Adagrasib… | Healthy Participants | Not Yet Recruiting |